Esrrg - estrogen-related receptor gamma Gene

Also Known as ERR3; Errg; NR3B3; mKIAA0832

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26381

About Esrrg

Chromosome 1: 187,340,988-187,947,082 forward strand.GRCm39:CM000994.3

This gene has 5 transcripts (splice variants), 136 orthologues, 8 paralogues and is associated with 23 phenotypes. Biased expression in cerebellum adult (RPKM 6.9), kidney adult (RPKM 4.9) and 12 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and sensory organ. Orthologous to human ESRRG (estrogen related receptor gamma). [provided by Alliance of Genome Resources, Apr 2022]

Esrrg Products (5)

mRNA Protein Name
NM_011935.3 NP_036065.1 estrogen-related receptor gamma isoform1
NM_001357536.1 NP_001344465.1 estrogen-related receptor gamma isoform 3
NM_001357534.1 NP_001344463.1 estrogen-related receptor gamma isoform 2
NM_001243792.1 NP_001230721.1 estrogen-related receptor gamma isoform 2
NM_001357535.1 NP_001344464.1 estrogen-related receptor gamma isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10428842 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
15149736 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15149736 MGI
enables estrogen response element binding IDA
IDA: Inferred from direct assay
10428842 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10428842 MGI
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12715898 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
17229846 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10428842 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15149736 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Esrrg Protein Structure

NR_DBD_ERR

NR_DBD_ERR: cd07170 (121 - 217)

NR_LBD_ERR

NR_LBD_ERR: cd06946 (236 - 455)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 458 a.a.
Protein Preferred Names Protein Names

estrogen-related receptor gamma

  • estrogen receptor-related protein 3

  • estrogen-related receptor 3

  • nuclear receptor subfamily 3 group B member 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04544 Esrrg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04543 ESRRG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04545 Esrrg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Esrrg NCBI NCBI:2104