AMELY - amelogenin Y-linked Gene

Homo sapiens

Also known as AMGL; AMGY

Gene ID: 266 | Gene type: protein coding

About AMELY

Cytogenetic location: Yp11.2 Genomic coordinates (GRCh38): Y:6,865,918-6,911,752 (from NCBI)

This gene has 2 transcripts (splice variants), 7 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in a related gene on chromosome X cause X-linked amelogenesis imperfecta. [provided by RefSeq, Jul 2008]

AMELY Products(2)

mRNA	Protein	Name
NM_001143.2	NP_001134.1	amelogenin, Y isoform isoform 1 precursor
NM_001364814.1	NP_001351743.1	amelogenin, Y isoform isoform 2 precursor

AMELY Protein Structure

Amelogenin

0
100
206 a.a.

Protein Preferred Names

Protein Names

amelogenin, Y isoform

amelogenin (Y chromosome)

Related Diseases

Diseases

Alias

Amelogenesis Imperfecta

Ai	Congenital Enamel Hypoplasia
Al - [Amelogenesis Imperfecta]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99308	Ocaratuzumab	Inhibitor	95.00%	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS00648	AMELY Human Pre-designed siRNA Set A	/	Unkown
HY-RS00649	AMER1 Human Pre-designed siRNA Set A	/	Unkown
HY-RS00650	AMER2 Human Pre-designed siRNA Set A	/	Unkown
HY-RS00651	AMER3 Human Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	AMELY	MGD	MGI:88005

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