Tor1a - torsin family 1, member A Gene

Also Known as Dyt1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 266606

Summary

Enables Kinesin binding activity. Involved in response to oxidative stress. Located in cytoplasmic vesicle and growth cone. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-5 and torsion dystonia 1. Orthologous to human TOR1A (torsin family 1 member A). [provided by Alliance of Genome Resources, Apr 2022]

Tor1a Products (1)

mRNA Protein Name
NM_153303.2 NP_695215.2 torsin-1A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables kinesin binding IDA
IDA: Inferred from direct assay
14970196 RGD
enables kinesin binding IPI
IPI: Inferred from physical interaction
14970196 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
21102408 RGD
Biological Process GO Annotation Evidence References Source
involved in response to oxidative stress IDA
IDA: Inferred from direct assay
12671990 RGD
Cellular Component GO Annotation Evidence References Source
located in growth cone IDA
IDA: Inferred from direct assay
14970196 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
18167355 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
21102408 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

torsin-1A

  • dystonia 1 protein

  • dystonia 1, torsion (autosomal dominant

  • dystonia 1, torsion (autosomal dominant

  • torsin A)

  • torsin A

  • torsin ATPase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14903 TOR1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22872 Tor1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29386 Tor1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tor1a NCBI NCBI:1861