Sptlc1 - serine palmitoyltransferase, long chain base subunit 1 Gene

Also Known as Lcb1; SPT1; E030036H05

Species: Mus musculus

Gene Type: protein coding
Gene ID: 268656

Summary

Enables serine C-palmitoyltransferase activity. Involved in regulation of fat cell apoptotic process and sphingomyelin biosynthetic process. Acts upstream of or within ceramide biosynthetic process; sphinganine biosynthetic process; and sphingosine biosynthetic process. Located in endoplasmic reticulum membrane. Is expressed in brain and liver. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 1A. Orthologous to human SPTLC1 (serine palmitoyltransferase long chain base subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Sptlc1 Products (1)

mRNA Protein Name
NM_009269.2 NP_033295.2 serine palmitoyltransferase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18484747 MGI
NOT enables serine C-palmitoyltransferase activity IDA
IDA: Inferred from direct assay
9363775 MGI
enables serine C-palmitoyltransferase activity IMP
IMP: Inferred from mutant phenotype
28100772 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within ceramide biosynthetic process IMP
IMP: Inferred from mutant phenotype
16216550 MGI
involved in regulation of fat cell apoptotic process IMP
IMP: Inferred from mutant phenotype
28100772 MGI
acts upstream of or within sphinganine biosynthetic process IMP
IMP: Inferred from mutant phenotype
19416652 MGI
involved in sphingolipid metabolic process IMP
IMP: Inferred from mutant phenotype
28100772 MGI
involved in sphingomyelin biosynthetic process IDA
IDA: Inferred from direct assay
26301690 MGI
acts upstream of or within sphingomyelin biosynthetic process IMP
IMP: Inferred from mutant phenotype
16216550 MGI
acts upstream of or within sphingosine biosynthetic process IMP
IMP: Inferred from mutant phenotype
16216550 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
26301690 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine palmitoyltransferase 1

  • long chain base biosynthesis protein 1

  • serine-palmitoyl-CoA transferase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS21943 Sptlc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13736 SPTLC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sptlc1 NCBI NCBI:10558