Rnf31 - ring finger protein 31 Gene

Also Known as HOIP; Paul; Flj10111; mFLJ00217

Species: Mus musculus

Gene Type: protein coding
Gene ID: 268749

Summary

Predicted to enable several functions, including linear polyubiquitin binding activity; polyubiquitin modification-dependent protein binding activity; and ubiquitin protein Ligase binding activity. Involved in CD40 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; and protein ubiquitination. Acts upstream of or within negative regulation of necroptotic process. Located in cytoplasmic side of plasma membrane and cytosol. Part of CD40 receptor complex. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and sensory organ. Orthologous to human RNF31 (ring finger protein 31). [provided by Alliance of Genome Resources, Apr 2022]

Rnf31 Products (1)

mRNA Protein Name
NM_194346.3 NP_919327.2 E3 ubiquitin-protein ligase RNF31

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14678832 MGI
enables ubiquitin protein ligase activity IMP
IMP: Inferred from mutant phenotype
19136968 MGI
Biological Process GO Annotation Evidence References Source
involved in CD40 signaling pathway IMP
IMP: Inferred from mutant phenotype
20614026 MGI
acts upstream of or within negative regulation of necroptotic process IGI
IGI: Inferred from genetic interaction
22089168 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
19136968 MGI
involved in protein polyubiquitination IMP
IMP: Inferred from mutant phenotype
19136968 MGI
involved in protein ubiquitination IMP
IMP: Inferred from mutant phenotype
20614026 MGI
Cellular Component GO Annotation Evidence References Source
part of CD40 receptor complex IDA
IDA: Inferred from direct assay
20614026 MGI
part of LUBAC complex IDA
IDA: Inferred from direct assay
19136968 MGI
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
14678832 MGI
located in cytosol IDA
IDA: Inferred from direct assay
14678832 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF31

  • HOIL-1-interacting protein

  • RING-type E3 ubiquitin transferase RNF31

  • putative Ariadne-like ubiquitin ligase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2478 Taraxasteryl acetate Inducer 98.74% Unkown
HY-RS12086 RNF31 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21036 Rnf31 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27553 Rnf31 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rnf31 NCBI NCBI:55072