Robo2 - roundabout guidance receptor 2 Gene

Also Known as mKIAA1568; 2600013A04Rik; 9430089E08Rik; D230004I22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 268902

Summary

Predicted to enable identical protein binding activity. Involved in several processes, including circulatory system development; neuron development; and positive regulation of Notch signaling pathway involved in heart induction. Acts upstream of or within axon guidance and metanephros development. Located in axolemma. Is expressed in several structures, including embryo mesenchyme; foot; jaw; nervous system; and urinary system. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Orthologous to human ROBO2 (roundabout guidance receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Robo2 Products (6)

mRNA Protein Name
NM_001358490.1 NP_001345419.1 roundabout homolog 2 isoform 4 precursor
NM_001358491.1 NP_001345420.1 roundabout homolog 2 isoform 3
NM_001358492.1 NP_001345421.1 roundabout homolog 2 isoform 2
NM_001358493.1 NP_001345422.1 roundabout homolog 2 isoform 1
NM_001358494.1 NP_001345423.1 roundabout homolog 2 isoform 6 precursor
NM_175549.5 NP_780758.3 roundabout homolog 2 isoform 5 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in aorta development IGI
IGI: Inferred from genetic interaction
25691540 MGI
involved in aortic valve morphogenesis IGI
IGI: Inferred from genetic interaction
25691540 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
15091338 MGI
involved in axon midline choice point recognition IGI
IGI: Inferred from genetic interaction
18986510 MGI
involved in endocardial cushion formation IGI
IGI: Inferred from genetic interaction
25691540 MGI
involved in heart induction IDA
IDA: Inferred from direct assay
25691540 MGI
acts upstream of or within metanephros development IMP
IMP: Inferred from mutant phenotype
15130495 MGI
involved in olfactory bulb interneuron development IMP
IMP: Inferred from mutant phenotype
17360927 MGI
involved in outflow tract septum morphogenesis IGI
IGI: Inferred from genetic interaction
25691540 MGI
involved in positive regulation of Notch signaling pathway IDA
IDA: Inferred from direct assay
25691540 MGI
involved in pulmonary valve morphogenesis IGI
IGI: Inferred from genetic interaction
25691540 MGI
involved in retinal ganglion cell axon guidance IMP
IMP: Inferred from mutant phenotype
19782674 MGI
involved in synapse maturation IDA
IDA: Inferred from direct assay
34686348 MGI
involved in synapse maturation IMP
IMP: Inferred from mutant phenotype
34686348 MGI
involved in ureteric bud development IMP
IMP: Inferred from mutant phenotype
15130495 MGI
involved in ventricular septum morphogenesis IGI
IGI: Inferred from genetic interaction
25691540 MGI
Cellular Component GO Annotation Evidence References Source
located in axolemma IDA
IDA: Inferred from direct assay
15084255 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
34686348 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
34686348 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
34686348 MGI
is active in postsynaptic density membrane IEP
IEP: Inferred from expression pattern
34686348 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

roundabout homolog 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12111 ROBO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18841 Robo2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25333 Robo2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990763 Sifarobocept 98.43% Unkown
HY-P992298 Anti-ROBO2 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Robo2 NCBI NCBI:6092