Lrig2 - leucine-rich repeats and immunoglobulin-like domains 2 Gene

Also Known as LIG-2; 4632419I10Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 269473

Summary

Enables signaling receptor binding activity. Acts upstream of or within several processes, including negative regulation of axon regeneration; negative regulation of membrane protein ectodomain proteolysis; and positive regulation of protein localization to cell surface. Located in several cellular components, including growth cone; intracellular vesicle; and neuronal cell body. Is expressed in several structures, including branchial arch; central nervous system; eye; inner ear; and nasal pit. Human ortholog(s) of this gene implicated in urofacial syndrome. Orthologous to human LRIG2 (leucine rich repeats and immunoglobulin like domains 2). [provided by Alliance of Genome Resources, Apr 2022]

Lrig2 Products (2)

mRNA	Protein	Name
NM_001025067.2	NP_001020238.1	leucine-rich repeats and immunoglobulin-like domains protein 2 isoform 1 precursor
NM_001310698.1	NP_001297627.1	leucine-rich repeats and immunoglobulin-like domains protein 2 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	26651291	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	26651291	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within innervation	IGI IGI: Inferred from genetic interaction	24086156	MGI
acts upstream of membrane protein ectodomain proteolysis	IMP IMP: Inferred from mutant phenotype	26651291	MGI
acts upstream of or within negative regulation of axon regeneration	IMP IMP: Inferred from mutant phenotype	26651291	MGI
acts upstream of or within negative regulation of membrane protein ectodomain proteolysis	IMP IMP: Inferred from mutant phenotype	26651291	MGI
acts upstream of or within negative regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	26651291	MGI
acts upstream of or within positive regulation of protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	26651291	MGI
acts upstream of protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	26651291	MGI
acts upstream of or within regulation of axon regeneration	IGI IGI: Inferred from genetic interaction	26651291	MGI
acts upstream of or within regulation of neuron migration	IGI IGI: Inferred from genetic interaction	26651291	MGI
acts upstream of or within regulation of platelet-derived growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	24023893	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	24086156	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in growth cone	IDA IDA: Inferred from direct assay	26651291	MGI
located in intracellular vesicle	IDA IDA: Inferred from direct assay	26651291	MGI
located in membrane	IDA IDA: Inferred from direct assay	26651291	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
leucine-rich repeats and immunoglobulin-like domains protein 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07788	LRIG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20982	Lrig2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27499	Lrig2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lrig2	NCBI	NCBI:9860