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Megf8 - multiple EGF-like-domains 8 Gene

Also Known as Egfl4; m687Ddg; b2b288Clo; mKIAA0817; b2b1702Clo; b2b1702.2Clo

Species: Mus musculus

Gene Type: protein coding

Gene ID: 269878

Summary

Predicted to enable calcium ion binding activity. Involved in several processes, including embryonic organ development; generation of neurons; and negative regulation of smoothened signaling pathway. Acts upstream of or within coronary vasculature development; determination of digestive tract left/right asymmetry; and determination of heart left/right asymmetry. Located in nucleus. Is expressed in several structures, including branchial arch; ganglia; heart; limb bud; and telencephalon. Used to study Carpenter syndrome and visceral heterotaxy. Human ortholog(s) of this gene implicated in Carpenter syndrome. Orthologous to human MEGF8 (multiple EGF like domains 8). [provided by Alliance of Genome Resources, Apr 2022]

Megf8 Products (1)

mRNA	Protein	Name
NM_001160400.1	NP_001153872.1	multiple epidermal growth factor-like domains protein 8 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32966817	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in BMP signaling pathway	IGI IGI: Inferred from genetic interaction	24052814	MGI
acts upstream of or within aorta development	IMP IMP: Inferred from mutant phenotype	32203821	MGI
acts upstream of or within coronary vasculature development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within determination of digestive tract left/right asymmetry	IMP IMP: Inferred from mutant phenotype	18043505	MGI
acts upstream of or within determination of heart left/right asymmetry	IMP IMP: Inferred from mutant phenotype	18043505	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within embryonic brain development	IMP IMP: Inferred from mutant phenotype	32203821	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	32203821	MGI
involved in embryonic heart tube left/right pattern formation	IMP IMP: Inferred from mutant phenotype	24052814	MGI
involved in embryonic heart tube morphogenesis	IMP IMP: Inferred from mutant phenotype	24052814	MGI
involved in embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	24052814	MGI
involved in embryonic skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	24052814	MGI
NOT acts upstream of or within epithelial cilium movement involved in determination of left/right asymmetry	IMP IMP: Inferred from mutant phenotype	18043505	MGI
involved in fasciculation of sensory neuron axon	IMP IMP: Inferred from mutant phenotype	24052814	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	32966817	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	32203821	MGI
acts upstream of or within left/right pattern formation	IMP IMP: Inferred from mutant phenotype	32203821	MGI
involved in left/right pattern formation	IMP IMP: Inferred from mutant phenotype	24052814	MGI
acts upstream of or within limb development	IMP IMP: Inferred from mutant phenotype	32966817	MGI
involved in negative regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	29290584	MGI
acts upstream of or within pharyngeal arch artery morphogenesis	IMP IMP: Inferred from mutant phenotype	32203821	MGI
involved in positive regulation of axon extension involved in axon guidance	IMP IMP: Inferred from mutant phenotype	24052814	MGI
acts upstream of or within protein ubiquitination	IDA IDA: Inferred from direct assay	32966817	MGI
acts upstream of or within protein ubiquitination	IMP IMP: Inferred from mutant phenotype	32966817	MGI
acts upstream of or within protein-containing complex assembly	IDA IDA: Inferred from direct assay	32966817	MGI
acts upstream of or within protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	32966817	MGI
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24052814	MGI
acts upstream of or within smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	32966817	MGI

Cellular Component GO Annotation	Evidence	References	Source
NOT located in membrane	IDA IDA: Inferred from direct assay	19218456	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19218456	MGI
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	32966817	MGI
part of ubiquitin ligase complex	IPI IPI: Inferred from physical interaction	32966817	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
multiple epidermal growth factor-like domains protein 8	EGF-like protein 4 EGF-like-domain, multiple 4 epidermal growth factor-like protein 4 multiple EGF-like domains protein 8

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08317	MEGF8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19022	Megf8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25511	Megf8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Megf8	NCBI	NCBI:1954