Sgsh - N-sulfoglucosamine sulfohydrolase (sulfamidase) Gene

Also Known as 4632406A19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 27029

Summary

Enables sulfuric ester hydrolase activity. Predicted to be involved in glycosaminoglycan catabolic process and heparan sulfate proteoglycan catabolic process. Predicted to act upstream of or within heparan sulfate proteoglycan metabolic process. Predicted to be located in lysosome. Used to study mucopolysaccharidosis III. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIIA. Orthologous to human SGSH (N-sulfoglucosamine sulfohydrolase). [provided by Alliance of Genome Resources, Apr 2022]

Sgsh Products (1)

mRNA Protein Name
NM_018822.3 NP_061292.2 N-sulphoglucosamine sulphohydrolase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables N-sulfoglucosamine sulfohydrolase activity IMP
IMP: Inferred from mutant phenotype
11181566 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15962010 MGI
enables sulfuric ester hydrolase activity IDA
IDA: Inferred from direct assay
15962010 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within determination of adult lifespan IGI
IGI: Inferred from genetic interaction
22867887 MGI
involved in heparan sulfate proteoglycan catabolic process IMP
IMP: Inferred from mutant phenotype
10561464 MGI
acts upstream of or within motor behavior IGI
IGI: Inferred from genetic interaction
22867887 MGI
Cellular Component GO Annotation Evidence Verweise Source
is active in lysosomal lumen IMP
IMP: Inferred from mutant phenotype
10561464 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

N-sulphoglucosamine sulphohydrolase

  • sulphamidase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-184063 Vexicitinib Inhibitor / Unkown
HY-RS12812 SGSH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19953 Sgsh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26455 Sgsh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sgsh NCBI NCBI:6448