PDE7B - phosphodiesterase 7B Gene

Also Known as bA472E5.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27115

About PDE7B

Cytogenetic location: 6q23.3 Genomic coordinates (GRCh38): 6:135,851,701-136,195,574 (from NCBI)

This gene has 3 transcripts (splice variants), 174 orthologues and 20 paralogues. Ubiquitous expression in ovary (RPKM 3.7), endometrium (RPKM 2.5) and 22 other tissues.

Summary

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.[provided by RefSeq, Apr 2009]

PDE7B Products (1)

mRNA Protein Name
NM_018945.4 NP_061818.1 cAMP-specific 3',5'-cyclic phosphodiesterase 7B

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
10814504 GOA
Biological Process GO Annotation Evidence References Source
involved in cAMP-mediated signaling IDA
IDA: Inferred from direct assay
10814504 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDE7B Protein Structure

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (172 - 396)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 450 a.a.
Protein Preferred Names Protein Names

cAMP-specific 3',5'-cyclic phosphodiesterase 7B

  • high-affinity cAMP-specific 3',5'-cyclic phosphodiesterase

Related Diseases

Diseases Alias
Dyslexia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-109586 BRL-50481 Inhibitor 99.81% Unkown
HY-170788 PDE7A-IN-1 Inhibitor 99.83% Unkown
HY-RS10241 PDE7B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W074537 P7-2104 Inhibitor 99.77% Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PDE7B MGD MGI:1352752
Bos taurus PDE7B VGNC VGNC:32686
Macaca mulatta PDE7B VGNC VGNC:75923
Rattus norvegicus PDE7B RGD RGD:621016
Canis familiaris PDE7B VGNC VGNC:44364
Felis catus PDE7B VGNC VGNC:68765
Others PDE7B NCBI