CHIA - chitinase acidic Gene

Also Known as CHIT2; AMCASE; TSA1902

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27159

About CHIA

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:111,290,851-111,320,563 (from NCBI)

This gene has 10 transcripts (splice variants), 253 orthologues and 6 paralogues. Biased expression in stomach (RPKM 2.7), lung (RPKM 1.9) and 2 other tissues.

Summary

The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

CHIA Products (8)

mRNA Protein Name
NM_001040623.3 NP_001035713.1 acidic mammalian chitinase isoform b
NM_001258001.2 NP_001244930.1 acidic mammalian chitinase isoform a
NM_001258002.2 NP_001244931.1 acidic mammalian chitinase isoform b
NM_001258003.2 NP_001244932.1 acidic mammalian chitinase isoform a
NM_001258004.2 NP_001244933.1 acidic mammalian chitinase isoform b
NM_001258005.2 NP_001244934.1 acidic mammalian chitinase isoform b
NM_021797.4 NP_068569.2 acidic mammalian chitinase isoform a
NM_201653.4 NP_970615.2 acidic mammalian chitinase isoform c precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chitinase activity IDA
IDA: Inferred from direct assay
19435888 GOA
enables kinase binding IPI
IPI: Inferred from physical interaction
18824549 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18824549 GOA
Biological Process GO Annotation Evidence References Source
involved in chitin catabolic process IDA
IDA: Inferred from direct assay
19435888 GOA
involved in positive regulation of chemokine production IDA
IDA: Inferred from direct assay
18824549 GOA
involved in production of molecular mediator involved in inflammatory response IDA
IDA: Inferred from direct assay
18824549 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
18824549 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHIA Protein Structure

Glyco_hydro_18

Glyco_hydro_18: Glycosyl hydrolases family 18 (23 - 365)

CBM_14

CBM_14: Chitin binding Peritrophin-A domain (430 - 476)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 476 a.a.
Protein Preferred Names Protein Names

acidic mammalian chitinase

  • lung-specific protein TSA1902

CHIA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CHIA Q9BZP6 RBBP8NL Homo sapiens Q8NC74
Y2H Array
32296183
Intra
CHIA Q9BZP6 RBBP8NL Homo sapiens Q8NC74
Y2H Prey Pooling
32296183
Intra
CHIA Q9BZP6 COX20 Homo sapiens Q5RI15
Y2H Array
32296183
Intra
CHIA Q9BZP6 COX20 Homo sapiens Q5RI15
Y2H Prey Pooling
32296183
Intra
CHIA Q9BZP6 EGFR Homo sapiens P00533
Anti Bait CoIP
18824549
Intra
CHIA Q9BZP6 TBC1D5 Homo sapiens Q92609
Y2H Prey Pooling
32296183
Intra
CHIA Q9BZP6 TBC1D5 Homo sapiens Q92609
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CHIA Proteins

Cat. No. Product Name Accession Purity
HY-P77869 AMCase/CHIA Protein, Human (HEK293, His) Q9BZP6 (Y22-A476) ≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases Alias
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Gaucher'S Disease

  • Gaucher Disease

  • Kerasin Thesaurismosis

  • Glucocerebrosidase Deficiency

  • Glucosylceramidase Deficiency

  • Cerebroside Lipidosis Syndrome

  • Acid Beta-Glucosidase Deficiency

  • Glucosylceramide Beta-Glucosidase Deficiency

  • Acute Cerebral Gaucher Disease

  • Gaucher Splenomegaly

  • Glucocerebrosidosis

  • Glucosyl Cerebroside Lipidosis

  • Kerasin Lipoidosis

  • Lipoid Histiocytosis

  • Glocucerebrosidase Deficiency

  • Sphingolipidosis 1

  • Gaucher Syndrome

  • Gauchers Disease

  • Gd

  • Glucosylceramide Lipidosis

  • Kerasin Histiocytosis

  • Gaucher Disease, Type 1

  • Gaucher Disease, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W017187 2-tert-Butyl-1,4-benzoquinone 99.34% Unkown
HY-N7624 Methyl oleanonate Agonist 99.93% Unkown
HY-N19960 Chia seed extract / Unkown
HY-N7003 28-Demethyl-β-amyrone Inhibitor / Unkown
HY-RS02628 CHIA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26383 Chia Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CHIA VGNC VGNC:55040
Canis familiaris CHIA VGNC VGNC:39214
Mus musculus CHIA MGD MGI:1932052
Rattus norvegicus CHIA RGD RGD:1303058
Macaca mulatta CHIA VGNC VGNC:70969
Felis catus CHIA VGNC VGNC:60856
Others CHIA NCBI