CHIA - chitinase acidic Gene

Homo sapiens

Also known as CHIT2; AMCASE; TSA1902

Gene ID: 27159 | Gene type: protein coding

About CHIA

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:111,290,851-111,320,563 (from NCBI)

This gene has 10 transcripts (splice variants), 253 orthologues and 6 paralogues. Biased expression in stomach (RPKM 2.7), lung (RPKM 1.9) and 2 other tissues.

Summary

The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

CHIA Products(8)

mRNA	Protein	Name
NM_001040623.3	NP_001035713.1	acidic mammalian chitinase isoform b
NM_001258001.2	NP_001244930.1	acidic mammalian chitinase isoform a
NM_001258002.2	NP_001244931.1	acidic mammalian chitinase isoform b
NM_001258003.2	NP_001244932.1	acidic mammalian chitinase isoform a
NM_001258004.2	NP_001244933.1	acidic mammalian chitinase isoform b
NM_001258005.2	NP_001244934.1	acidic mammalian chitinase isoform b
NM_021797.4	NP_068569.2	acidic mammalian chitinase isoform a
NM_201653.4	NP_970615.2	acidic mammalian chitinase isoform c precursor

CHIA Protein Structure

Glyco_hydro_18

CBM_14

0
100
200
300
400
476 a.a.

Protein Preferred Names

Protein Names

acidic mammalian chitinase

lung-specific protein TSA1902

Recombinant CHIA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77869	AMCase/CHIA Protein, Human (HEK293, His)	Q9BZP6 (Y22-A476)	≥95%

Related Diseases

Diseases

Alias

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Gaucher'S Disease

Gaucher Disease	Kerasin Thesaurismosis
Glucocerebrosidase Deficiency	Glucosylceramidase Deficiency
Cerebroside Lipidosis Syndrome	Acid Beta-Glucosidase Deficiency
Glucosylceramide Beta-Glucosidase Deficiency	Acute Cerebral Gaucher Disease
Gaucher Splenomegaly	Glucocerebrosidosis
Glucosyl Cerebroside Lipidosis	Kerasin Lipoidosis
Lipoid Histiocytosis	Glocucerebrosidase Deficiency
Sphingolipidosis 1	Gaucher Syndrome
Gauchers Disease	Gd
Glucosylceramide Lipidosis	Kerasin Histiocytosis
Gaucher Disease, Type 1	Gaucher Disease, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N7624	Methyl oleanonate	Agonist	99.79%	Unkown
HY-N7003	28-Demethyl-β-amyrone	Inhibitor	/	Unkown
HY-RS02628	CHIA Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CHIA	VGNC	VGNC:55040
Canis familiaris	CHIA	VGNC	VGNC:39214
Mus musculus	CHIA	MGD	MGI:1932052
Rattus norvegicus	CHIA	RGD	RGD:1303058
Macaca mulatta	CHIA	VGNC	VGNC:70969
Felis catus	CHIA	VGNC	VGNC:60856
Others	CHIA	NCBI

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