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TOX3 - TOX high mobility group box family member 3 Gene

Also Known as CAGF9; TNRC9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27324

About TOX3

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:52,436,416-52,547,802 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues and 20 paralogues. Biased expression in stomach (RPKM 5.0), colon (RPKM 3.6) and 13 other tissues.

Summary

The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast Cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]

TOX3 Products (2)

mRNA	Protein	Name
NM_001080430.4	NP_001073899.2	TOX high mobility group box family member 3 isoform 1
NM_001146188.2	NP_001139660.1	TOX high mobility group box family member 3 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	21172805	GOA
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	21172805	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21172805	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	21172805	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	21172805	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	21172805	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21172805	GOA
involved in regulation of apoptotic process	IDA IDA: Inferred from direct assay	21172805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOX3 Protein Structure

HMG_box

0
100
200
300
400
500
576 a.a.

Protein Preferred Names	Protein Names
TOX high mobility group box family member 3	CAG trinucleotide repeat-containing gene F9 protein

Related Diseases

Diseases	Alias
Restless Legs Syndrome	Wed Willis-Ekbom Disease Restless Leg Syndrome Ekbom Syndrome Wittmaack-Ekbom Syndrome Willis Ekbom Disease Ekbom'S Syndrome Rls Restless Legs Restless Legs Syndrome, Susceptibility To
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Sporadic Breast Cancer	Sporadic Breast Carcinoma
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14910	TOX3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22349	Tox3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TOX3	VGNC	VGNC:55004
Mus musculus	TOX3	MGD	MGI:3039593
Macaca mulatta	TOX3	VGNC	VGNC:78612
Rattus norvegicus	TOX3	RGD	RGD:1311529
Bos taurus	TOX3	VGNC	VGNC:36229