2. Gene
  3. KCNMB4 - potassium calcium-activated channel subfamily M regulatory beta subunit 4 Gene

KCNMB4 - potassium calcium-activated channel subfamily M regulatory beta subunit 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 27345 | Gene type: protein coding

About KCNMB4

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:70,366,290-70,434,292 (from NCBI)

This gene has 2 transcripts (splice variants), 180 orthologues and 3 paralogues. Broad expression in brain (RPKM 7.6), adrenal (RPKM 4.7) and 15 other tissues.

Summary

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008]

KCNMB4 Products(1)

mRNA Protein Name
NM_014505.6 NP_055320.4 calcium-activated potassium channel subunit beta-4

KCNMB4 Protein Structure

CaKB

CaKB: Calcium-activated potassium channel, beta subunit (5 - 204)

  • 0
  • 100
  • 210 a.a.
Protein Preferred Names Protein Names

calcium-activated potassium channel subunit beta-4

BK channel beta subunit 4

Related Diseases

Diseases Alias
Developmental And Epileptic Encephalopathy 52

DEE52

Epileptic Encephalopathy, Early Infantile, 52

Eiee52

Developmental And Epileptic Encephalopathy, 52

Early Infantile Epileptic Encephalopathy 52
Parosteal Osteosarcoma

Juxtacortical Osteosarcoma

Parosteal Osteogenic Sarcoma

Osteosarcoma, Juxtacortical
Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07168 KCNMB4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus KCNMB4 VGNC VGNC:67925
Rattus norvegicus KCNMB4 RGD RGD:620728
Macaca mulatta KCNMB4 VGNC VGNC:74001
Mus musculus KCNMB4 MGD MGI:1913272
Bos taurus KCNMB4 VGNC VGNC:30482