KCNMB4 - potassium calcium-activated channel subfamily M regulatory beta subunit 4 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27345

About KCNMB4

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:70,366,290-70,434,292 (from NCBI)

This gene has 2 transcripts (splice variants), 180 orthologues and 3 paralogues. Broad expression in brain (RPKM 7.6), adrenal (RPKM 4.7) and 15 other tissues.

Summary

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008]

KCNMB4 Products (1)

mRNA	Protein	Name
NM_014505.6	NP_055320.4	calcium-activated potassium channel subunit beta-4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium-activated potassium channel activity	IDA IDA: Inferred from direct assay	10692449	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10692449	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in action potential	IDA IDA: Inferred from direct assay	10692449	GOA
involved in detection of calcium ion	IDA IDA: Inferred from direct assay	10692449	GOA
involved in neuronal action potential	IDA IDA: Inferred from direct assay	10692449	GOA
involved in potassium ion transport	IDA IDA: Inferred from direct assay	10692449	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	10692449	GOA
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	10692449	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNMB4 Protein Structure

CaKB

0
100
200
210 a.a.

Protein Preferred Names	Protein Names
calcium-activated potassium channel subunit beta-4	BK channel beta subunit 4

Related Diseases

Diseases	Alias
Developmental And Epileptic Encephalopathy 52	DEE52 Epileptic Encephalopathy, Early Infantile, 52 Eiee52 Developmental And Epileptic Encephalopathy, 52 Early Infantile Epileptic Encephalopathy 52
Parosteal Osteosarcoma	Juxtacortical Osteosarcoma Parosteal Osteogenic Sarcoma Osteosarcoma, Juxtacortical
Bone Osteosarcoma	Osteosarcoma Of Bone Primary Osteosarcoma Of Bone
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07168	KCNMB4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KCNMB4	VGNC	VGNC:67925
Rattus norvegicus	KCNMB4	RGD	RGD:620728
Macaca mulatta	KCNMB4	VGNC	VGNC:74001
Mus musculus	KCNMB4	MGD	MGI:1913272
Bos taurus	KCNMB4	VGNC	VGNC:30482
Others	KCNMB4	NCBI