Pdhx - pyruvate dehydrogenase complex, component X Gene

Also Known as E3bp; Pdx1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 27402

Summary

Predicted to enable Acyltransferase activity. Predicted to contribute to pyruvate dehydrogenase (NAD+) activity. Predicted to act upstream of or within mitochondrial acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion. Is expressed in several structures, including alimentary system; musculature; nervous system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHX (pyruvate dehydrogenase complex component X). [provided by Alliance of Genome Resources, Apr 2022]

Pdhx Products (1)

mRNA Protein Name
NM_175094.5 NP_780303.1 pyruvate dehydrogenase protein X component, mitochondrial

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in acetyl-CoA biosynthetic process from pyruvate IMP
IMP: Inferred from mutant phenotype
17314311 MGI
Cellular Component GO Annotation Evidence References Source
is active in mitochondrial matrix IDA
IDA: Inferred from direct assay
9405644 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pyruvate dehydrogenase protein X component, mitochondrial

  • dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex (E3-binding protein) (proX)

  • lipoyl-containing pyruvate dehydrogenase complex component X

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10264 PDHX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21404 Pdhx Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27923 Pdhx Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdhx NCBI NCBI:8050