MET - MET proto-oncogene, receptor tyrosine kinase Gene

Bos taurus

Also known as HGFR; c-met

Gene ID: 280855 | Gene type: protein coding

About MET

Primary_assembly 4: 51,622,340-51,735,652 reverse strand.ARS-UCD1.2:CM008171.2

This gene has 2 transcripts (splice variants), 207 orthologues and 56 paralogues.

mRNA	Protein	Name
NM_001012999.2	NP_001013017.2	hepatocyte growth factor receptor precursor

Sema

PSI

IPT_plexin_repeat1

IPT

IPT_plexin_repeat3

IPT_PCSR

PTKc_Met_Ron

Protein Preferred Names

Protein Names

hepatocyte growth factor receptor

HGF receptor c-Met	HGF/SF receptor
SF receptor	met proto-oncogene (hepatocyte growth factor receptor)
met proto-oncogene tyrosine kinase	proto-oncogene c-Met
scatter factor receptor	tyrosine-protein kinase Met

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13016	Cabozantinib	Inhibitor	99.97%	Yes
HY-13404	Capmatinib	Inhibitor	99.71%	Yes

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16446	SAR125844	Inhibitor	98.17%	Phase 2
HY-12035	AMG-208	Inhibitor	99.86%	Phase 2
HY-50683	JNJ-38877605	Inhibitor	99.95%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99455	Bafisontamab	Inhibitor	99.9%	Phase 3

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114357A	DS-1205b free base	Inhibitor	99.92%	Unkown
HY-168135	PROTAC c-Met degrader-1	Degrader	98.48%	Unkown
HY-157551	JNK-IN-16	Inhibitor	99.82%	Unkown
HY-183579	c-Met-IN-27	Inhibitor	/	Unkown
HY-179034	CAIX/XII-IN-16	Inhibitor	/	Unkown
HY-162803	c-Met-IN-24	Inhibitor	/	Unkown
HY-171824	PROTAC c-Met Degrader-4	Degrader	/	Unkown
HY-D3352	EMI-137		/	Unkown
HY-175321	PROTAC c-Met degrader-6	Degrader	/	Unkown
HY-178348	PARP1/c-Met-IN-2	Inhibitor	/	Unkown
HY-157387	c-Met-IN-22	Inhibitor	/	Unkown
HY-181928	PARP1/c-Met-IN-3	Inhibitor	/	Unkown
HY-179098	Multi-target kinase-IN-8	Inhibitor	/	Unkown
HY-123237	KRC-108	Inhibitor	/	Unkown
HY-161372	PARP1/c-Met-IN-1	Inhibitor	/	Unkown
HY-120908	c-Met-IN-16	Inhibitor	/	Unkown
HY-181776	VEGFR-2/c-Met/EGFR-IN-2	Inhibitor	/	Unkown
HY-175848	NSC 850745	Inhibitor	/	Unkown
HY-177134	Taligantinib	Inhibitor	/	Unkown
HY-149675	VEGFR-2/c-Met-IN-2	Inhibitor	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992481	VERT-002	Degrader	/	Unkown
HY-P991565	CE-355621	Inhibitor	/	Unkown

Species	Symbol	Source	ID
Homo sapiens	MET	NCBI	NCBI:4233
Canis familiaris	MET	NCBI	NCBI:403438
Macaca fascicularis	MET	NCBI	NCBI:102123512
Mus musculus	MET	NCBI	NCBI:17295
Susscrofa domestica	MET	NCBI
Rattus norvegicus	MET	NCBI	NCBI:24553
Macaca mulatta	MET	NCBI	NCBI:704562

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