1. Protein Tyrosine Kinase/RTK
  2. c-Met/HGFR

SAR125844 

Cat. No.: HY-16446 Purity: 99.03%
Handling Instructions

SAR125844 is a potent, highly selective, reversible and ATP-competitive MET receptor tyrosine kinase (RTK) inhibitor, with an IC50 of 4.2 nM. Shows inhibition of MET autophosphorylation in cell-based assays.

For research use only. We do not sell to patients.

SAR125844 Chemical Structure

SAR125844 Chemical Structure

CAS No. : 1116743-46-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 145 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 190 In-stock
Estimated Time of Arrival: December 31
50 mg USD 750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1300 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

SAR125844 is a potent, highly selective, reversible and ATP-competitive MET receptor tyrosine kinase (RTK) inhibitor, with an IC50 of 4.2 nM. Shows inhibition of MET autophosphorylation in cell-based assays[1].

IC50 & Target

IC50: 4.2 nM (MET RTK)[1].

Solvent & Solubility
In Vitro: 

DMSO : 45 mg/mL (81.72 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8161 mL 9.0805 mL 18.1610 mL
5 mM 0.3632 mL 1.8161 mL 3.6322 mL
10 mM 0.1816 mL 0.9081 mL 1.8161 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.25 mg/mL (4.09 mM); Clear solution

References
Molecular Weight

550.63

Formula

C₂₅H₂₃FN₈O₂S₂

CAS No.

1116743-46-4

SMILES

O=C(NCCN1CCOCC1)NC2=NC3=CC=C(SC4=NN=C5C=CC(C6=CC=C(F)C=C6)=NN54)C=C3S2

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Inquiry Information

Product Name:
SAR125844
Cat. No.:
HY-16446
Quantity:

SAR125844

Cat. No.: HY-16446