Tinf2 - Terf1 (TRF1)-interacting nuclear factor 2 Gene

Also Known as Tin2; D14Wsu146e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 28113

Summary

Enables telomeric DNA binding activity. Acts upstream of or within negative regulation of telomere maintenance. Located in chromosome, telomeric region. Is expressed in several structures, including brain ventricular layer; olfactory epithelium; submandibular gland primordium; thymus primordium; and vibrissa. Used to study dyskeratosis congenita. Human ortholog(s) of this gene implicated in Revesz syndrome and autosomal dominant dyskeratosis congenita 3. Orthologous to human TINF2 (TERF1 interacting nuclear factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Tinf2 Products (7)

mRNA Protein Name
NM_001404599.1 NP_001391528.1 TERF1-interacting nuclear factor 2 isoform 1
NM_001404600.1 NP_001391529.1 TERF1-interacting nuclear factor 2 isoform 2
NM_001404601.1 NP_001391530.1 TERF1-interacting nuclear factor 2 isoform 4
NM_001404602.1 NP_001391531.1 TERF1-interacting nuclear factor 2 isoform 5
NM_001404603.1 NP_001391532.1 TERF1-interacting nuclear factor 2 isoform 6
NM_001404604.1 NP_001391533.1 TERF1-interacting nuclear factor 2 isoform 7
NM_145705.4 NP_663751.2 TERF1-interacting nuclear factor 2 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12676566 MGI
enables telomeric DNA binding IDA
IDA: Inferred from direct assay
23685356 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of telomere maintenance IDA
IDA: Inferred from direct assay
12676566 MGI
Cellular Component GO Annotation Evidence References Source
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
12676566 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TERF1-interacting nuclear factor 2

  • TRF1-interacting nuclear factor 2

  • TRF1-interacting nuclear protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14545 TINF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22863 Tinf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29377 Tinf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tinf2 NCBI NCBI:26277