SLCO4A1 - solute carrier organic anion transporter family member 4A1 Gene

Also Known as POAT; OATP1; OATPE; OATP-E; OATP4A1; OATPRP1; SLC21A12

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 28231

About SLCO4A1

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:62,642,503-62,690,740 (from NCBI)

This gene has 9 transcripts (splice variants), 208 orthologues and 10 paralogues. Ubiquitous expression in esophagus (RPKM 2.4), endometrium (RPKM 1.6) and 23 other tissues.

Summary

Predicted to enable sodium-independent organic anion transmembrane transporter activity and thyroid hormone transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLCO4A1 Products (1)

mRNA	Protein	Name
NM_016354.4	NP_057438.3	solute carrier organic anion transporter family member 4A1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables organic anion transmembrane transporter activity	IDA IDA: Inferred from direct assay	10873595	GOA
enables prostaglandin transmembrane transporter activity	IDA IDA: Inferred from direct assay	10873595	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLCO4A1 Protein Structure

OATP

Kazal_2

0
200
400
600
722 a.a.

Protein Preferred Names	Protein Names
solute carrier organic anion transporter family member 4A1	OATP-RP1

Related Diseases

Diseases	Alias
Primary Hypertrophic Osteoarthropathy	Pachydermoperiostosis Syndrome Osteoarthropathy, Primary Hypertrophic Pachydermoperiostosis Of Nail Idiopathic Hypertrophic Osteoarthropathy Pho
Myasthenic Syndrome, Congenital, 1b, Fast-Channel	CMS1B Congenital Myasthenic Syndrome 1b Myasthenic Syndrome, Congenital, Fast-Channel Congenital Myasthenic Syndrome 1b, Fast-Channel Fccms Myasthenic Syndrome, Fast-Channel Congenital Myasthenic Syndrome, Congenital, Type 1b, Fast-Channel Congenital Myasthenic Syndrome Ib
Intrahepatic Cholestasis Of Pregnancy	Recurrent Intrahepatic Cholestasis Of Pregnancy Gravidic Intrahepatic Cholestasis Pregnancy-Related Cholestasis Icp Pregnancy Related Cholestasis Cholestasis, Intrahepatic Of Pregnancy Familial Intrahepatic Cholestasis Of Pregnancy Familial Recurrent Intrahepatic Cholestasis Of Pregnancy Ricp Obstetric Cholestasis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13358	SLCO4A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13359	SLCO4C1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SLCO4A1	VGNC	VGNC:65447
Bos taurus	SLCO4A1	VGNC	VGNC:34954
Rattus norvegicus	SLCO4A1	RGD	RGD:620228
Macaca mulatta	SLCO4A1	VGNC	VGNC:77599
Mus musculus	SLCO4A1	MGD	MGI:1351866
Canis familiaris	SLCO4A1	VGNC	VGNC:46498