GPR4 - G protein-coupled receptor 4 Gene

Also Known as GPR6C.l

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2828

About GPR4

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,589,764-45,602,212 (from NCBI)

This gene has 2 transcripts (splice variants), 141 orthologues and 16 paralogues. Broad expression in fat (RPKM 4.0), lung (RPKM 2.3) and 22 other tissues.

Summary

Enables G protein-coupled receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of Rho protein signal transduction; and response to acidic pH. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR4 Products (1)

mRNA Protein Name
NM_005282.3 NP_005273.1 G-protein coupled receptor 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IMP
IMP: Inferred from mutant phenotype
20211729 GOA
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
17462861 GOA
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12955148 GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
20211729 GOA
involved in positive regulation of Rho protein signal transduction IDA
IDA: Inferred from direct assay
17462861 GOA
involved in positive regulation of Rho protein signal transduction IMP
IMP: Inferred from mutant phenotype
20211729 GOA
involved in regulation of cell adhesion IDA
IDA: Inferred from direct assay
22110680 GOA
involved in response to acidic pH IDA
IDA: Inferred from direct assay
17462861 GOA
involved in response to acidic pH IMP
IMP: Inferred from mutant phenotype
12955148 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
20211729 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR4 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (35 - 286)

  • 0
  • 100
  • 200
  • 300
  • 362 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor 4

  • G-protein coupled receptor 19

  • G-protein coupled receptor 6C.l

Related Diseases

Diseases Alias
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Cancer Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Congenital Central Hypoventilation Syndrome

  • Cchs

  • Haddad Syndrome

  • Ondine Curse

  • Ondine Syndrome

  • Congenital Central Hypoventilation

  • Congenital Central Alveolar Hypoventilation Syndrome

  • Congenital Failure Of Autonomic Control

  • Ondine'S Curse

  • Primary Alveolar Hypoventilation

  • Ondine-Hirschsprung Disease

  • Central Congenital Hypoventilation Syndrome

  • Congenital Ondine Curse

  • Idiopathic Congenital Central Alveolar Hypoventilation

  • Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome

  • Ondine-Hirschsprung Syndrome
Prolactin Producing Pituitary Tumor

  • Prolactin-Producing Pituitary Gland Carcinoma

  • Prolactin-Producing Pituitary Tumor

  • Malignant Prolactin Producing Neoplasm Of Pituitary Gland

  • Malignant Prolactinoma

  • Prolactin Producing Pituitary Tumour

  • Prolactin Secreting Tumor Of Pituitary

  • Prolactin Secreting Tumour Of Pituitary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101784 NE 52-QQ57 99.80% Unkown
HY-101536 GPR4 antagonist 1 Antagonist 98.92% Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GPR4 VGNC VGNC:67427
Macaca mulatta GPR4 VGNC VGNC:73136
Canis familiaris GPR4 VGNC VGNC:41435
Rattus norvegicus GPR4 RGD RGD:1311604
Mus musculus GPR4 MGD MGI:2441992
Bos taurus GPR4 VGNC VGNC:29587
Others GPR4 NCBI