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GPR15 - G protein-coupled receptor 15 Gene

Also Known as BOB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2838

About GPR15

Cytogenetic location: 3q11.2 Genomic coordinates (GRCh38): 3:98,531,978-98,534,681 (from NCBI)

This gene has 1 transcript (splice variant), 120 orthologues and 7 paralogues.

Summary

This gene encodes a G protein-coupled receptor that acts as a Chemokine Receptor for human immunodeficiency virus type 1 and 2. The encoded protein localizes to the cell membrane. [provided by RefSeq, Nov 2012]

GPR15 Products (1)

mRNA	Protein	Name
NM_005290.4	NP_005281.1	G-protein coupled receptor 15

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	28900043	GOA
enables coreceptor activity	IDA IDA: Inferred from direct assay	15650194	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28936214	GOA
enables virus receptor activity	IDA IDA: Inferred from direct assay	15650194	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	28900043	GOA
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	28386128	GOA
involved in symbiont entry into host cell	IDA IDA: Inferred from direct assay	15650194	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11696454	GOA
located in endosome	IDA IDA: Inferred from direct assay	28615320	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	28615320	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR15 Protein Structure

7tm_1

0
100
200
300
360 a.a.

Protein Preferred Names	Protein Names
G-protein coupled receptor 15	brother of Bonzo

GPR15 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84356	GPR15 Antibody (YA4053)	ICC/IF, FC, ELISA	Human
HY-P84356A	GPR15 Antibody (YA4053)(PBS only)	ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Human Immunodeficiency Virus Type 1	Aids Hiv/Aids Aids, Delayed/Rapid Progression To Hiv-1, Susceptibility To Hiv-1 Viremia, Susceptibility To Human Immunodeficiency Virus Type 1, Susceptibility To Hiv-1 Aids, Slow Progression To Rapid Progression To Aids From Hiv1 Infection Hiv1 Infection, Resistance To Hiv1 Infection Hiv-1 Viremia Aids, Resistance To Aids, Rapid Progression To Hiv/Aids, Susceptibility To Hiv-1, Resistance To Hiv1, Resistance To Hiv1 Hiv-1 Disease, Delayed Progression Of Hiv-1 Disease, Rapid Progression Of Hiv Infection, Resistance To Hiv Type 1, Susceptibility To Hiv Type 1 Hiv-1 Infection Human Immunodeficiency Virus I Infection Acquired Immunodeficiency Syndrome Hiv-Infection/Aids
Gray Zone Lymphoma	B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma
Thymus Basaloid Carcinoma	Basaloid Carcinoma Of The Thymus Thymic Basaloid Carcinoma
Mediastinal Gray Zone Lymphoma	Mediastinal B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma
Mediastinal Malignant Lymphoma	Lymphoma Of Mediastinum Mediastinal Lymphoma
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2196A	ELA-32(human) TFA	Agonist	99.93%	Unkown
HY-177116	GPR15 antagonist-1		99.70%	Unkown
HY-RS05668	GPR15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19438	Gpr15 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25929	Gpr15 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GPR15	VGNC	VGNC:73125
Felis catus	GPR15	VGNC	VGNC:67416
Mus musculus	GPR15	MGD	MGI:1918473
Rattus norvegicus	GPR15	RGD	RGD:1306639
Bos taurus	GPR15	VGNC	VGNC:29557
Canis familiaris	GPR15	VGNC	VGNC:41404
Others	GPR15	NCBI