Flnb - filamin, beta Gene

Also Known as Fln-b

Species: Mus musculus

Gene Type: protein coding
Gene ID: 286940

Summary

Predicted to enable identical protein binding activity. Acts upstream of or within several processes, including cellular response to interferon-gamma; epithelial cell development; and skeletal muscle tissue development. Located in several cellular components, including brush border; focal adhesion; and stress fiber. Is expressed in several structures, including alimentary system; brain; limb mesenchyme; sensory organ; and skeleton. Used to study spondylocarpotarsal synostosis syndrome. Human ortholog(s) of this gene implicated in Larsen syndrome; bone development disease (multiple); cleft palate; and spinal disease (multiple). Orthologous to human FLNB (filamin B). [provided by Alliance of Genome Resources, Apr 2022]

Flnb Products (2)

mRNA Protein Name
NM_001081427.1 NP_001074896.1 filamin-B isoform a
NM_134080.1 NP_598841.1 filamin-B isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12393796 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
24012369 MGI
acts upstream of or within cellular response to type II interferon IDA
IDA: Inferred from direct assay
19144319 MGI
acts upstream of or within epithelial cell morphogenesis IMP
IMP: Inferred from mutant phenotype
24012369 MGI
acts upstream of or within keratinocyte development IMP
IMP: Inferred from mutant phenotype
24012369 MGI
acts upstream of or within skeletal muscle tissue development IDA
IDA: Inferred from direct assay
11807098 MGI
Cellular Component GO Annotation Evidence References Source
located in brush border IDA
IDA: Inferred from direct assay
22114352 MGI
located in focal adhesion IDA
IDA: Inferred from direct assay
11807098 MGI
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
19144319 MGI
located in stress fiber IDA
IDA: Inferred from direct assay
11807098 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

filamin-B

  • ABP-280-like protein

  • actin binding protein 278

  • actin-binding-like protein

  • beta-filamin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04980 FLNB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19898 Flnb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26399 Flnb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Flnb NCBI NCBI:2317