Stub1 - STIP1 homology and U-box containing protein 1 Gene

Also Known as Chip

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 287155

Summary

Enables chaperone binding activity. Involved in several processes, including cellular response to hypoxia; chaperone-mediated autophagy; and response to ischemia. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 16 and cerebellar ataxia type 48. Orthologous to human STUB1 (STIP1 homology and U-box containing protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Stub1 Products (1)

mRNA	Protein	Name
NM_001025625.2	NP_001020796.2	E3 ubiquitin-protein ligase CHIP

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15671027	RGD
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	20724525	RGD
enables ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	19237536	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in MAPK cascade	IMP IMP: Inferred from mutant phenotype	20724525	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	30980393	RGD
involved in negative regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	30980393	RGD
involved in negative regulation of smooth muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19483080	RGD
involved in negative regulation of vascular associated smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	19237536	RGD
involved in positive regulation of mitophagy	IMP IMP: Inferred from mutant phenotype	29934347	RGD
involved in positive regulation of smooth muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	21808025	RGD
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	19237536	RGD
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	19483080	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19237536	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	29934347	RGD
located in nucleus	IDA IDA: Inferred from direct assay	19237536	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase CHIP	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase carboxy terminus of Hsp70-interacting protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W1128879	XMU-MP-8	Degrader	99.23%	Unkown
HY-RS13972	STUB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-175686	E3 ligase Ligand 67		98.69%	Unkown
HY-RS17083	Stub1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23527	Stub1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stub1	NCBI	NCBI:10273