GPX2 - glutathione peroxidase 2 Gene

Also Known as GPRP; GPx-2; GI-GPx; GPRP-2; GPx-GI; GSHPx-2; GSHPX-GI

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2877

About GPX2

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:64,939,158-64,942,745 (from NCBI)

This gene has 4 transcripts (splice variants), 194 orthologues and 7 paralogues. Biased expression in gall bladder (RPKM 164.4), stomach (RPKM 114.6) and 8 other tissues.

Summary

The protein encoded by this gene belongs to the Glutathione Peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal Cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]

GPX2 Products (1)

mRNA Protein Name
NM_002083.4 NP_002074.2 glutathione peroxidase 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glutathione peroxidase activity IDA
IDA: Inferred from direct assay
8428933 GOA
enables phospholipid-hydroperoxide glutathione peroxidase activity IDA
IDA: Inferred from direct assay
36608588 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
8428933 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPX2 Protein Structure

GSHPx

GSHPx: Glutathione peroxidase (8 - 120)

  • 0
  • 100
  • 190 a.a.
Protein Preferred Names Protein Names

glutathione peroxidase 2

  • gastrointestinal glutathione peroxidase

GPX2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82408 Glutathione Peroxidase 2 Antibody (YA2153) WB, IHC-P Human

Related Diseases

Diseases Alias
Ileocolitis

  • Iieocolitis
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Barrett Esophagus

  • Barrett'S Esophagus

  • Barrett Esophagus/Esophageal Adenocarcinoma

  • Barrett Metaplasia

  • Barrett'S Ulcer Of Esophagus

  • Ulcerative Esophagitis

  • Barrett'S Esophagus With Esophagitis

  • Barrett'S Oesophagus

  • Barretts Syndrome

  • Barrett Syndrome

  • BE

  • Peptic Ulcer Of Esophagus

  • Adenocarcinoma Of Esophagus
Benign Ileal Neoplasm

  • Ileal Tumor

  • Ileal Neoplasms

  • Ileal Neoplasm
Anemia, Nonspherocytic Hemolytic, Due To G6pd Deficiency

  • Favism

  • Favism, Susceptibility To

  • Hemolytic Anemia, G6pd Deficient

  • Class I Glucose-6-Phosphate Dehydrogenase Deficiency

  • Class I G6pd Deficiency

  • Severe Hemolytic Anemia Due To G6pd Deficiency

  • Anemia, Non-Spherocytic Hemolytic, Due To G6pd Deficiency

  • NSHA

  • G6pd Deficient Hemolytic Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136788 ALK4290 Inhibitor 99.79% Unkown
HY-RS05765 GPX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25431 Gpx2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18941 Gpx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GPX2 VGNC VGNC:80961
Mus musculus GPX2 MGD MGI:106609
Canis familiaris GPX2 VGNC VGNC:41462
Rattus norvegicus GPX2 RGD RGD:727780
Bos taurus GPX2 VGNC VGNC:29618
Macaca mulatta GPX2 VGNC VGNC:73152
Others GPX2 NCBI