Pkp2 - plakophilin 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 287925

Summary

Predicted to enable several functions, including alpha-catenin binding activity; intermediate filament binding activity; and protein kinase C binding activity. Involved in several processes, including cell-cell junction organization; lipid homeostasis; and regulation of bicellular tight junction assembly. Located in adherens junction and intercalated disc. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and arrhythmogenic right ventricular dysplasia 9. Orthologous to human PKP2 (plakophilin 2). [provided by Alliance of Genome Resources, Apr 2022]

Pkp2 Products (1)

mRNA Protein Name
NM_001100499.1 NP_001093969.1 plakophilin-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21062920 RGD
Biological Process GO Annotation Evidence References Source
involved in adherens junction maintenance IMP
IMP: Inferred from mutant phenotype
18261826 RGD
involved in cardiac muscle cell action potential IMP
IMP: Inferred from mutant phenotype
19661460 RGD
involved in gap junction assembly IMP
IMP: Inferred from mutant phenotype
17673670 RGD
involved in lipid homeostasis IMP
IMP: Inferred from mutant phenotype
21985446 RGD
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
21985446 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
21985446 RGD
involved in positive regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
21617128 RGD
involved in regulation of bicellular tight junction assembly IMP
IMP: Inferred from mutant phenotype
19509333 RGD
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
16406610 RGD
located in cell junction IDA
IDA: Inferred from direct assay
26858265 RGD
located in desmosome IDA
IDA: Inferred from direct assay
21617128 RGD
located in intercalated disc IDA
IDA: Inferred from direct assay
19661460 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

plakophilin-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10612 PKP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20326 Pkp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26834 Pkp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pkp2 NCBI NCBI:5318