Gart - phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 288259

Summary

Enables phosphoribosylamine-glycine Ligase activity; phosphoribosylformylglycinamidine cyclo-ligase activity; and phosphoribosylglycinamide formyltransferase activity. Involved in several processes, including brain development; brainstem development; and tetrahydrofolate biosynthetic process. Predicted to be active in cytosol. Orthologous to human GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase). [provided by Alliance of Genome Resources, Apr 2022]

Gart Products (1)

mRNA Protein Name
NM_001011899.2 NP_001011899.2 trifunctional purine biosynthetic protein adenosine-3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables phosphoribosylamine-glycine ligase activity IDA
IDA: Inferred from direct assay
3532702 RGD
enables phosphoribosylformylglycinamidine cyclo-ligase activity IDA
IDA: Inferred from direct assay
3532702 RGD
enables phosphoribosylglycinamide formyltransferase activity IDA
IDA: Inferred from direct assay
3532702 RGD
Biological Process GO Annotation Evidence References Source
involved in brainstem development IEP
IEP: Inferred from expression pattern
7057182 RGD
involved in cerebellum development IEP
IEP: Inferred from expression pattern
7057182 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
7057182 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

trifunctional purine biosynthetic protein adenosine-3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05280 GART Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18934 Gart Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25424 Gart Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gart NCBI NCBI:2618