Lig4 - DNA ligase 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 290907

Summary

Enables ATP binding activity; DNA binding activity; and DNA Ligase (ATP) activity. Involved in DNA ligation and cellular response to lithium ion. Located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including DNA Ligase IV deficiency; colorectal cancer; high grade glioma; multiple myeloma; and prostate Cancer. Orthologous to human LIG4 (DNA Ligase 4). [provided by Alliance of Genome Resources, Apr 2022]

Lig4 Products (1)

mRNA Protein Name
NM_001106095.1 NP_001099565.1 DNA ligase 4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
9600082 RGD
enables DNA binding IDA
IDA: Inferred from direct assay
9600082 RGD
enables DNA ligase (ATP) activity IDA
IDA: Inferred from direct assay
9600082 RGD
Biological Process GO Annotation Evidence References Source
involved in DNA ligation IDA
IDA: Inferred from direct assay
9600082 RGD
involved in cellular response to lithium ion IEP
IEP: Inferred from expression pattern
19285016 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA ligase 4

  • DNA ligase (ATP) 4

  • ligase IV, DNA, ATP-dependent

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07644 LIG4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19909 Lig4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26410 Lig4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lig4 NCBI NCBI:3981