RANGRF - RAN guanine nucleotide release factor Gene

Also Known as MOG1; HSPC165; HSPC236; RANGNRF

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29098

About RANGRF

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,288,670-8,290,087 (from NCBI)

This gene has 6 transcripts (splice variants), 176 orthologues and is associated with 1 phenotype. Broad expression in testis (RPKM 13.3), endometrium (RPKM 7.1) and 24 other tissues.

Summary

This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac Sodium Channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

RANGRF Products (4)

mRNA	Protein	Name
NM_001177801.2	NP_001171272.1	ran guanine nucleotide release factor isoform B
NM_001177802.2	NP_001171273.1	ran guanine nucleotide release factor isoform C
NM_001330127.2	NP_001317056.1	ran guanine nucleotide release factor isoform D
NM_016492.5	NP_057576.2	ran guanine nucleotide release factor isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	11290418	GOA
enables sodium channel regulator activity	IDA IDA: Inferred from direct assay	18184654	GOA
enables sodium channel regulator activity	IMP IMP: Inferred from mutant phenotype	23420830	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	18184654	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	23420830	GOA
involved in mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	29040603	GOA
involved in positive regulation of protein localization to cell surface	IDA IDA: Inferred from direct assay	18184654	GOA
involved in positive regulation of protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	23420830	GOA
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	23420830	GOA
involved in protein exit from endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	23420830	GOA
involved in regulation of bundle of His cell action potential	IMP IMP: Inferred from mutant phenotype	21621375	GOA
involved in regulation of cardiac muscle cell action potential involved in regulation of contraction	IMP IMP: Inferred from mutant phenotype	21621375	GOA
involved in regulation of membrane depolarization	IDA IDA: Inferred from direct assay	18184654	GOA
involved in regulation of membrane depolarization	IMP IMP: Inferred from mutant phenotype	23420830	GOA
involved in regulation of membrane depolarization during cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	21621375	GOA
involved in regulation of membrane potential	IDA IDA: Inferred from direct assay	18184654	GOA
involved in regulation of sodium ion transmembrane transport	IDA IDA: Inferred from direct assay	18184654	GOA
involved in regulation of sodium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	21621375	GOA
involved in regulation of sodium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	18184654	GOA
involved in regulation of sodium ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	21621375	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in caveola	IDA IDA: Inferred from direct assay	23420830	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11290418	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11290418	GOA
located in rough endoplasmic reticulum	IDA IDA: Inferred from direct assay	23420830	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RANGRF Protein Structure

Mog1

0
100
186 a.a.

Protein Preferred Names	Protein Names
ran guanine nucleotide release factor	MOG1 homolog

Related Diseases

Diseases	Alias
Brugada Syndrome	Sudden Unexpected Nocturnal Death Syndrome Sudden Unexplained Nocturnal Death Syndrome Bangungut Brugada Type Idiopathic Ventricular Fibrillation Pokkuri Death Syndrome Sunds Idiopathic Ventricular Fibrillation, Brugada Type Sudden Unexplained Death Dream Disease Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sudden Unexplained Death Syndrome Suds Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Sick Sinus Syndrome	Sinus Node Dysfunction Sinus Node Disease Sinus Node Infection Snd Sss Snd - [Sinus Node Dysfunction] Sinoatrial Node Dysfunction Sss - [Sick Sinus Syndrome] Sick Sinus Sick Sinus Tachycardia
Sinoatrial Node Disease	Sa Node Sinuatrial Node Sinus Node Dysfunction
Right Bundle Branch Block	Right Bundle Branch Block With Left Posterior Fascicular Block
Long Qt Syndrome 2	LQT2 Long Qt Syndrome, Acquired, Reduced Susceptibility To Long Qt Syndrome 1/2 Long Qt Syndrome 2/3 Long Qt Syndrome 2/5 Long Qt Syndrome 2, Acquired, Susceptibility To Long Qt Syndrome, Acquired, Reduced Long Qt Syndrome Type 2 Long Qt Syndrome 2/9 Lqt1/2 Lqt2/3 Lqt2/5 Lqt2/9 Susceptibility To Acquired Long Qt Syndrome 2 Long Qt Syndrome-2 Qt Syndrome, Long, Type 2 Long Qt Syndrome 1-2 Long Qt Syndrome 2-3 Long Qt Syndrome 2-5 Long Qt Syndrome 9
Catecholaminergic Polymorphic Ventricular Tachycardia	Cpvt Catecholamine-Induced Polymorphic Ventricular Tachycardia Familial Polymorphic Ventricular Tachycardia Malignant Paroxysmal Ventricular Tachycardia Multifocal Ventricular Premature Beats Stress-Induced Polymorphic Ventricular Tachycardia Bidirectional Tachycardia Induced By Catecholamine Double Tachycardia Induced By Catecholamines Polymorphic Catecholergic Ventricular Tachycardia Syncopal Paroxysmal Tachycardia Bidirectional Tachycardia Induced By Catecholamines Fpvt Bidirectional Ventricular Tachycardia Induced By Catecholamine Polymorphic Ventricular Tachycardia Induced By Catecholamines Ventricular Tachycardia, Catecholaminergic Polymorphic Ventricular Tachycardia, Catecholaminergic Polymorphic, 1 Familial Ventricular Tachycardia Multifocal Pvcs Multifocal Premature Ventricular Beats
Long Qt Syndrome 1	Romano-Ward Syndrome LQT1 Ward-Romano Syndrome Rws Ventricular Fibrillation With Prolonged Qt Interval Wrs Long Qt Syndrome 1, Acquired, Susceptibility To Long Qt Syndrome 1, Acquired Romano-Ward Long Qt Syndrome Long Qt Syndrome Type 1 Long Qt Syndrome-1 Acquired Susceptibility To Long Qt Syndrome 1 Qt Syndrome, Long, Type 1
Long Qt Syndrome	Romano-Ward Syndrome Long Q-T Syndrome Lqt Qt Syndrome, Long Congenital Long Qt Syndrome Familial Long Qt Syndrome
Familial Atrial Fibrillation	Atrial Fibrillation, Familial Atfb Atrial Fibrillation Autosomal Dominant Autosomal Dominant Atrial Fibrillation Auricular Fibrillation Atrial Fibrillation Atrial Fibrillation, Familial, 1
Left Ventricular Noncompaction	Noncompaction Cardiomyopathy Left Ventricular Hypertrabeculation Lvnc Spongy Myocardium Isolated Noncompaction Of The Ventricular Myocardium Left Ventricular Myocardial Noncompaction Cardiomyopathy Fetal Myocardium Honeycomb Myocardium Hypertrabeculation Syndrome Left Ventricular Non-Compaction Lvht Non-Compaction Of The Left Ventricular Myocardium Ventricular Noncompaction, Left Non-Compaction Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11651	RANGRF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RANGRF	VGNC	VGNC:33714
Mus musculus	RANGRF	MGD	MGI:1889073
Macaca mulatta	RANGRF	VGNC	VGNC:76503
Canis familiaris	RANGRF	VGNC	VGNC:45341
Rattus norvegicus	RANGRF	RGD	RGD:1563195
Others	RANGRF	NCBI