Nedd4l - NEDD4 like E3 ubiquitin protein ligase Gene

Also Known as Nedd4-2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 291553

Summary

Enables Potassium Channel Inhibitor activity and ubiquitin-protein transferase activity. Involved in several processes, including positive regulation of caveolin-mediated endocytosis; protein monoubiquitination; and ventricular cardiac muscle cell action potential. Predicted to be active in cytoplasm. Predicted to colocalize with plasma membrane. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human NEDD4L (NEDD4 like E3 ubiquitin protein Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Nedd4l Products (1)

mRNA Protein Name
NM_001401320.1 NP_001388249.1 E3 ubiquitin-protein ligase NEDD4-like

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables potassium channel inhibitor activity IMP
IMP: Inferred from mutant phenotype
22879586 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
22417925 RGD
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
19953087 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of potassium ion transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
22879586 RGD
involved in positive regulation of caveolin-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
22879586 RGD
involved in positive regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
18174164 RGD
involved in protein monoubiquitination IMP
IMP: Inferred from mutant phenotype
21332718 RGD
involved in ventricular cardiac muscle cell action potential IMP
IMP: Inferred from mutant phenotype
22879586 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase NEDD4-like

  • neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09180 NEDD4L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17116 Nedd4l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23561 Nedd4l Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nedd4l NCBI NCBI:23327