Ercc1 - ERCC excision repair 1, endonuclease non-catalytic subunit Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 292673

Summary

Predicted to enable several functions, including DNA binding activity; TFIID-class transcription factor complex binding activity; and promoter-specific chromatin binding activity. Predicted to contribute to 3' overhang single-stranded DNA endodeoxyribonuclease activity and DNA binding activity. Involved in several processes, including response to cadmium ion; response to immobilization stress; and response to sucrose. Located in nucleus. Used to study lung carcinoma. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including bone Cancer (multiple); carcinoma (multiple); cerebrooculofacioskeletal syndrome 4; hematologic Cancer (multiple); and transient cerebral ischemia. Orthologous to human ERCC1 (ERCC excision repair 1, Endonuclease non-catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]

Ercc1 Products (1)

mRNA Protein Name
NM_001106228.1 NP_001099698.1 DNA excision repair protein ERCC-1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in embryonic organ development IEP
IEP: Inferred from expression pattern
11425516 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
25729986 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
25726146 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
14670002 RGD
involved in response to sucrose IEP
IEP: Inferred from expression pattern
15145517 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA excision repair protein ERCC-1

  • excision repair cross-complementation group 1

  • excision repair cross-complementing 1

  • excision repair cross-complementing rodent repair deficiency, complementation group 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100690 NSC16168 Inhibitor 98.11% Unkown
HY-147356 ERCC1-XPF-IN-2 Inhibitor 98.54% Unkown
HY-143498 ERCC1-XPF-IN-1 Inhibitor 99.37% Unkown
HY-RS04478 ERCC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-161623 ERCC1/XPA interaction inhibitor 1 Inhibitor / Unkown
HY-RS18274 Ercc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24752 Ercc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ercc1 NCBI NCBI:2067