Adora2b - adenosine A2B receptor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29316

About Adora2b

Primary_assembly 10: 46,940,384-46,956,772 forward strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 200 orthologues, 3 paralogues and is associated with 9 phenotypes. Biased expression in Lung (RPKM 18.9), Brain (RPKM 17.7) and 9 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity. Involved in several processes, including negative regulation of Collagen biosynthetic process; positive regulation of cAMP-mediated signaling; and positive regulation of interleukin-6 production. Located in cell surface and plasma membrane. Orthologous to human ADORA2B (adenosine A2b receptor). [provided by Alliance of Genome Resources, Apr 2022]

Adora2b Products (1)

mRNA Protein Name
NM_017161.2 NP_058857.2 adenosine receptor A2b

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11230362 RGD
involved in negative regulation of collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
9535419 RGD
involved in positive regulation of cAMP/PKA signal transduction IMP
IMP: Inferred from mutant phenotype
8012696 RGD
involved in positive regulation of catecholamine secretion IMP
IMP: Inferred from mutant phenotype
18823369 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12021208 RGD
involved in positive regulation of endothelial cell migration IMP
IMP: Inferred from mutant phenotype
11882603 RGD
involved in positive regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
11882603 RGD
involved in positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
26385692 RGD
involved in positive regulation of norepinephrine secretion IMP
IMP: Inferred from mutant phenotype
15223300 RGD
involved in positive regulation of steroid biosynthetic process IMP
IMP: Inferred from mutant phenotype
18582595 RGD
involved in regulation of glucose metabolic process IMP
IMP: Inferred from mutant phenotype
26385692 RGD
involved in response to angiotensin IMP
IMP: Inferred from mutant phenotype
26385692 RGD
involved in vasodilation IDA
IDA: Inferred from direct assay
10666062 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
12021208 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Adora2b Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (7 - 300)

7tm_GPCRs

7tm_GPCRs: cd14964 (9 - 33)

7tm_GPCRs

7tm_GPCRs: cd14964 (42 - 64)

7tm_GPCRs

7tm_GPCRs: cd14964 (78 - 100)

7tm_GPCRs

7tm_GPCRs: cd14964 (123 - 139)

7tm_GPCRs

7tm_GPCRs: cd14964 (179 - 202)

7tm_GPCRs

7tm_GPCRs: cd14964 (232 - 254)

7tm_GPCRs

7tm_GPCRs: cd14964 (268 - 293)

  • 0
  • 100
  • 200
  • 300
  • 332 a.a.
Protein Preferred Names Protein Names

adenosine receptor A2b

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00397 ADORA2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00398 Adora2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00399 Adora2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adora2b NCBI NCBI:136