Fgf8 - fibroblast growth factor 8 Gene

Also Known as Fgf6c

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29349

Summary

Enables chemoattractant activity. Involved in several processes, including neuron development; odontogenesis; and response to oxidative stress. Located in external side of plasma membrane. Biomarker of hypospadias. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 6 with or without anosmia and prostate carcinoma in situ. Orthologous to human FGF8 (Fibroblast Growth Factor 8). [provided by Alliance of Genome Resources, Apr 2022]

Fgf8 Products (2)

mRNA Protein Name
NM_001414191.1 NP_001401120.1 fibroblast growth factor 8 isoform 1 precursor
NM_133286.2 NP_579820.1 fibroblast growth factor 8 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chemoattractant activity IMP
IMP: Inferred from mutant phenotype
12403710 RGD
Biological Process GO Annotation Evidence References Source
involved in central nervous system neuron development IMP
IMP: Inferred from mutant phenotype
9630220 RGD
involved in dorsal/ventral axon guidance IMP
IMP: Inferred from mutant phenotype
12403710 RGD
involved in forebrain neuron development IMP
IMP: Inferred from mutant phenotype
9630220 RGD
involved in motor neuron axon guidance IMP
IMP: Inferred from mutant phenotype
12403710 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
19464577 RGD
involved in response to oxidative stress IDA
IDA: Inferred from direct assay
10350562 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
15786497 RGD
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
9531542 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibroblast growth factor 8

  • fibroblast growth factor 6c

  • fibroblast growth factor 8 (androgen-induced)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04906 FGF8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174692 Human FGF8 mRNA / Unkown
HY-RS17743 Fgf8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24209 Fgf8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fgf8 NCBI NCBI:2253