Rab7a - RAB7A, member RAS oncogene family Gene

Also Known as Rab7

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29448

Summary

Enables GDP binding activity; GTP binding activity; and small GTPase binding activity. Involved in bone resorption. Located in alveolar lamellar body and late endosome. Is anchored component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B. Orthologous to human RAB7A (RAB7A, member Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Rab7a Products (1)

mRNA Protein Name
NM_023950.4 NP_076440.1 ras-related protein Rab-7a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GDP binding IDA
IDA: Inferred from direct assay
16040606 RGD
enables GTP binding IDA
IDA: Inferred from direct assay
16040606 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15186776 RGD
enables small GTPase binding IPI
IPI: Inferred from physical interaction
16040606 RGD
Biological Process GO Annotation Evidence References Source
involved in bone resorption IMP
IMP: Inferred from mutant phenotype
11514537 RGD
involved in synaptic vesicle recycling via endosome EXP
EXP: Inferred from Experiment
29950309 RGD
involved in synaptic vesicle recycling via endosome IDA
IDA: Inferred from direct assay
29950309 RGD
Cellular Component GO Annotation Evidence References Source
located in alveolar lamellar body IDA
IDA: Inferred from direct assay
7868367 RGD
located in late endosome IDA
IDA: Inferred from direct assay
19337031 RGD
is active in presynaptic endosome IDA
IDA: Inferred from direct assay
29950309 RGD
is active in presynaptic endosome IMP
IMP: Inferred from mutant phenotype
31074746 RGD
is active in synaptic vesicle membrane EXP
EXP: Inferred from Experiment
20926670 RGD
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
20926670 RGD
is active in synaptic vesicle membrane IMP
IMP: Inferred from mutant phenotype
20926670 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ras-related protein Rab-7a

  • RAB7, member RAS oncogene family

  • ras-related protein BRL-RAS

  • ras-related protein p23

Recombinant Rab7a Proteins

Cat. No. Product Name Accession Purity
HY-P75998 RAB7A Protein, Rat (His, solution) P09527 (M1-C207) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11576 RAB7A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29509 Rab7a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183772 TBC1D2-IN-1 / Unkown
HY-RS23154 Rab7a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rab7a NCBI NCBI:7879