Krt18 - keratin 18 Gene

Also Known as Krt1-18

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 294853

Summary

Predicted to enable scaffold protein binding activity. Involved in several processes, including cholangiocyte apoptotic process; hepatocyte differentiation; and response to fructose. Located in several cellular components, including external side of plasma membrane; extracellular space; and keratin filament. Part of protein-containing complex. Biomarker of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Human ortholog(s) of this gene implicated in liver cirrhosis. Orthologous to human KRT18 (keratin 18). [provided by Alliance of Genome Resources, Apr 2022]

Krt18 Products (1)

mRNA Protein Name
NM_053976.1 NP_446428.1 keratin, type I cytoskeletal 18

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cholangiocyte apoptotic process IEP
IEP: Inferred from expression pattern
30563999 RGD
involved in hepatocyte differentiation IEP
IEP: Inferred from expression pattern
24340101 RGD
involved in mesenchymal stem cell differentiation IEP
IEP: Inferred from expression pattern
18484094 RGD
involved in response to fructose IEP
IEP: Inferred from expression pattern
29989845 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
24071521 RGD
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
9353322 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
24071521 RGD
located in keratin filament IDA
IDA: Inferred from direct assay
1709097 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
9353322 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

keratin, type I cytoskeletal 18

  • CK-18

  • K18

  • cytokeratin-18

  • keratin 18, type I

  • keratin complex 1, acidic, gene 18

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07441 KRT18 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19704 Krt18 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26199 Krt18 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Krt18 NCBI NCBI:3875