Slc10a2 - solute carrier family 10 member 2 Gene

Also Known as ASBT; IBAT; ISBT; ISBAT

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29500

About Slc10a2

Primary_assembly 16: 84,374,862-84,409,475 forward strand.mRatBN7.2:CM026989.1

This gene has 2 transcripts (splice variants), 212 orthologues, 6 paralogues and is associated with 8 phenotypes. Biased expression in Kidney (RPKM 2.9), Testes (RPKM 1.9) and 1 other tissue.

Summary

Enables bile acid:sodium symporter activity. Involved in bile acid and bile salt transport. Located in apical plasma membrane and nucleus. Part of Proteasome complex. Human ortholog(s) of this gene implicated in intestinal disease. Orthologous to human SLC10A2 (solute carrier family 10 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc10a2 Products (1)

mRNA Protein Name
NM_017222.2 NP_058918.1 ileal sodium/bile acid cotransporter

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables bile acid:sodium symporter activity IDA
IDA: Inferred from direct assay
8770054 RGD
Biological Process GO Annotation Evidence References Source
involved in bile acid and bile salt transport IDA
IDA: Inferred from direct assay
8770054 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
8770054 RGD
part of proteasome complex IDA
IDA: Inferred from direct assay
15304498 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc10a2 Protein Structure

bass

bass: TIGR00841 (28 - 314)

  • 0
  • 100
  • 200
  • 300
  • 348 a.a.
Protein Preferred Names Protein Names

ileal sodium/bile acid cotransporter

  • Na(+)-dependent ileal bile acid transporter

  • apical sodium-dependent bile acid transporter

  • ileal Na(+)/bile acid cotransporter

  • ileal sodium-dependent bile acid transporter

  • sodium/taurocholate-cotransporting polypeptide, ileal

  • solute carrier family 10 (sodium/bile acid cotransporter family), member 2

  • solute carrier family 10 (sodium/bile acid cotransporter), member 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12986 SLC10A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12987 Slc10a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12988 Slc10a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-168523 S1647 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc10a2 NCBI NCBI:6555