Sp7 - Sp7 transcription factor Gene

Also Known as Osx

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 300260

Summary

Predicted to enable DEAD/H-box RNA helicase binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in hematopoietic stem cell differentiation; positive regulation of stem cell differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within osteoblast differentiation. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 12. Orthologous to human SP7 (Sp7 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Sp7 Products (2)

mRNA Protein Name
NM_001037632.1 NP_001032721.1 transcription factor Sp7 isoform 1
NM_181374.2 NP_852039.2 transcription factor Sp7 isoform 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to zinc ion starvation IEP
IEP: Inferred from expression pattern
21893222 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
20818503 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
20818503 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor Sp7

  • osterix

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W019901B Anhydrous calcium sulfate (97%) Activator 99.40% Unkown
HY-15977 (S)-P7C3-OMe / Unkown
HY-162568 7-tert-Butylfascaplysin / Unkown
HY-RS13610 SP7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17939 Sp7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24410 Sp7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sp7 NCBI NCBI:121340