Top3a - DNA topoisomerase III alpha Gene
Species: Rattus norvegicus
Gene Type: protein coding
Gene ID: 303194
Summary
Predicted to enable DNA Topoisomerase type I (single strand cut, ATP-independent) activity and single-stranded DNA binding activity. Predicted to be involved in DNA topological change; chromosome separation; and mitochondrial DNA metabolic process. Predicted to be located in PML body. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5. Orthologous to human TOP3A (DNA Topoisomerase III alpha). [provided by Alliance of Genome Resources, Apr 2022]
Top3a Products (3)
| mRNA | Protein | Name |
|---|---|---|
| XM_039087263.1 | XP_038943191.1 | DNA topoisomerase 3-alpha isoform X1 |
| XM_039087264.1 | XP_038943192.1 | DNA topoisomerase 3-alpha isoform X2 |
| XM_039087265.1 | XP_038943193.1 | DNA topoisomerase 3-alpha isoform X3 |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
DNA topoisomerase 3-alpha |
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(3)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS14898 | TOP3A Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS21791 | Top3a Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS28307 | Top3a Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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