Gna13 - G protein subunit alpha 13 Gene

Also Known as Galpha13

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 303634

Summary

Enables D5 Dopamine Receptor binding activity. Involved in activation of Phospholipase D activity and positive regulation of cytosolic calcium ion concentration. Acts upstream of or within G protein-coupled receptor signaling pathway; negative regulation of vascular associated smooth muscle cell migration; and negative regulation of vascular associated smooth muscle cell proliferation. Located in brush border membrane. Orthologous to human GNA13 (G protein subunit alpha 13). [provided by Alliance of Genome Resources, Apr 2022]

Gna13 Products (1)

mRNA Protein Name
NM_001013119.1 NP_001013137.1 guanine nucleotide-binding protein subunit alpha-13

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D5 dopamine receptor binding IPI
IPI: Inferred from physical interaction
12623966 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12509430 RGD
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
29453251 RGD
involved in G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9092554 RGD
involved in activation of phospholipase D activity IMP
IMP: Inferred from mutant phenotype
12435801 RGD
acts upstream of or within negative regulation of vascular associated smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
29453251 RGD
acts upstream of or within negative regulation of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
29453251 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
9092554 RGD
Cellular Component GO Annotation Evidence References Source
located in brush border membrane IDA
IDA: Inferred from direct assay
12623966 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanine nucleotide-binding protein subunit alpha-13

  • G alpha-13

  • guanine nucleotide binding protein (G protein), alpha 13

  • guanine nucleotide binding protein, alpha 13

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05531 GNA13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20938 Gna13 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27455 Gna13 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gna13 NCBI NCBI:10672