Muc4 - mucin 4, cell surface associated Gene

Also Known as Psmc; ASGP-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 303887

Summary

Enables ErbB-2 class receptor binding activity. Involved in several processes, including estrous cycle; negative regulation of T cell mediated cytotoxicity directed against tumor cell target; and negative regulation of cell adhesion. Located in several cellular components, including apical plasma membrane; extracellular space; and microvillus membrane. Part of protein-containing complex. Colocalizes with endoplasmic reticulum. Biomarker of cholangiocarcinoma; corneal neovascularization; mucositis; and otitis media. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human MUC4 (Mucin 4, cell surface associated). [provided by Alliance of Genome Resources, Apr 2022]

Muc4 Products (1)

mRNA Protein Name
XM_039088927.1 XP_038944855.1 mucin-4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ErbB-2 class receptor binding IPI
IPI: Inferred from physical interaction
15499570 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
20054827 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
10980611 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
9857062 RGD
involved in digestive tract development IEP
IEP: Inferred from expression pattern
15389518 RGD
involved in estrous cycle IEP
IEP: Inferred from expression pattern
9618151 RGD
involved in lactation IEP
IEP: Inferred from expression pattern
15499570 RGD
involved in mammary gland development IEP
IEP: Inferred from expression pattern
15499570 RGD
involved in negative regulation of T cell mediated cytotoxicity directed against tumor cell target IDA
IDA: Inferred from direct assay
10232613 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
19293191 RGD
involved in negative regulation of cell-cell adhesion IDA
IDA: Inferred from direct assay
9407114 RGD
involved in negative regulation of cell-matrix adhesion IDA
IDA: Inferred from direct assay
9407114 RGD
involved in post-embryonic camera-type eye development IEP
IEP: Inferred from expression pattern
11120573 RGD
involved in regulation of signaling receptor activity IDA
IDA: Inferred from direct assay
10026131 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
12668667 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
9618151 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
17495032 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
9618151 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
10634605 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18998135 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
15499570 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
12186632 RGD
located in microvillus membrane IDA
IDA: Inferred from direct assay
2674161 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
20054827 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mucin-4

  • ASGP

  • MUC-4

  • ascites sialoglycoprotein

  • pancreatic adenocarcinoma mucin

  • pre-sialomucin complex

  • sialomucin ascites sialoglycoprotein-1

  • sialomucin complex

  • testis mucin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS19923 Muc4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08843 MUC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26425 Muc4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Muc4 NCBI NCBI:4585