Cpox - coproporphyrinogen oxidase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 304024

Summary

Enables coproporphyrinogen oxidase activity and identical protein binding activity. Involved in several processes, including protoporphyrinogen IX biosynthetic process; response to lead ion; and response to methylmercury. Located in mitochondrial inner membrane and mitochondrial intermembrane space. Human ortholog(s) of this gene implicated in hereditary coproporphyria and liver disease. Orthologous to human CPOX (coproporphyrinogen oxidase). [provided by Alliance of Genome Resources, Apr 2022]

Cpox Products (1)

mRNA Protein Name
NM_001037095.1 NP_001032172.1 oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables coproporphyrinogen oxidase activity IDA
IDA: Inferred from direct assay
11079369 RGD
enables identical protein binding IDA
IDA: Inferred from direct assay
11079369 RGD
Biological Process GO Annotation Evidence References Source
involved in heme biosynthetic process IDA
IDA: Inferred from direct assay
3955059 RGD
involved in protoporphyrinogen IX biosynthetic process IDA
IDA: Inferred from direct assay
3814086 RGD
involved in response to arsenic-containing substance IEP
IEP: Inferred from expression pattern
2916235 RGD
involved in response to insecticide IEP
IEP: Inferred from expression pattern
6626236 RGD
involved in response to iron ion IEP
IEP: Inferred from expression pattern
2289051 RGD
involved in response to lead ion IEP
IEP: Inferred from expression pattern
656697 RGD
involved in response to methylmercury IEP
IEP: Inferred from expression pattern
2916235 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
31872 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

  • COX

  • coprogen oxidase

  • coproporphyrinogen-III oxidase, mitochondrial

  • coproporphyrinogenase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03112 CPOX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20261 Cpox Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26769 Cpox Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cpox NCBI NCBI:1371