Chuk - component of inhibitor of nuclear factor kappa B kinase complex Gene

Also Known as Ikka; Ikbka

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 309361

About Chuk

Primary_assembly 1: 242,959,760-242,995,065 reverse strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 266 orthologues, 3 paralogues and is associated with 19 phenotypes. Biased expression in Kidney (RPKM 214.9), Liver (RPKM 178.7) and 9 other tissues.

Summary

Contributes to IkappaB kinase activity. Involved in several processes, including Rho protein signal transduction; response to cholecystokinin; and response to lipopolysaccharide. Located in cytosol and intracellular membrane-bounded organelle. Part of IkappaB kinase complex. Used to study muscular atrophy. Biomarker of colitis. Human ortholog(s) of this gene implicated in fetal encasement syndrome and prostate Cancer. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex). [provided by Alliance of Genome Resources, Apr 2022]

Chuk Products (1)

mRNA Protein Name
NM_001107588.1 NP_001101058.1 inhibitor of nuclear factor kappa-B kinase subunit alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
17419723 RGD
Biological Process GO Annotation Evidence References Source
involved in response to acetate IEP
IEP: Inferred from expression pattern
17543437 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
17543437 RGD
involved in response to cholecystokinin IDA
IDA: Inferred from direct assay
12592100 RGD
involved in response to hydroperoxide IEP
IEP: Inferred from expression pattern
16028365 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
12361703 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16331110 RGD
involved in skeletal muscle contraction IEP
IEP: Inferred from expression pattern
15888549 RGD
involved in striated muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
11279241 RGD
Cellular Component GO Annotation Evidence References Source
part of IkappaB kinase complex IDA
IDA: Inferred from direct assay
17419723 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Chuk Protein Structure

STKc_IKK_alpha

STKc_IKK_alpha: cd14039 (20 - 308)

Ubl_IKKA_like

Ubl_IKKA_like: cd17046 (310 - 386)

IKBKB_SDD

IKBKB_SDD: pfam18397 (385 - 658)

  • 0
  • 200
  • 400
  • 600
  • 758 a.a.
Protein Preferred Names Protein Names

inhibitor of nuclear factor kappa-B kinase subunit alpha

  • conserved helix-loop-helix ubiquitous kinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02698 CHUK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02699 Chuk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02700 Chuk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chuk NCBI NCBI:1147