Tiparp - TCDD-inducible poly(ADP-ribose) polymerase Gene

Also Known as RM1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 310467

About Tiparp

Primary_assembly 2: 149,753,682-149,780,327 forward strand.mRatBN7.2:CM026975.1

This gene has 2 transcripts (splice variants), 208 orthologues, 7 paralogues and is associated with 1 phenotype. Biased expression in Heart (RPKM 15.5), Lung (RPKM 117.2) and 9 other tissues.

Summary

Predicted to enable NAD+ ADP-ribosyltransferase activity; cis-regulatory region sequence-specific DNA binding activity; and protein ADP-ribosylase activity. Involved in response to 2,3,7,8-tetrachlorodibenzodioxine. Predicted to be located in nucleus. Orthologous to human TIPARP (TCDD inducible poly(ADP-ribose) polymerase). [provided by Alliance of Genome Resources, Apr 2022]

Tiparp Products (2)

mRNA Protein Name
NM_001107679.3 NP_001101149.2 protein mono-ADP-ribosyltransferase TIPARP
NM_001107679.3 NP_001101149.2 protein mono-ADP-ribosyltransferase TIPARP

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in response to 2,3,7,8-tetrachlorodibenzodioxine IEP
IEP: Inferred from expression pattern
24355419 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tiparp Protein Structure

WWE

WWE: pfam02825 (347 - 400)

TCCD_inducible_PARP_like

TCCD_inducible_PARP_like: cd01439 (528 - 647)

  • 0
  • 200
  • 400
  • 600
  • 657 a.a.
Protein Preferred Names Protein Names

protein mono-ADP-ribosyltransferase TIPARP

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-181027 TIPARP-IN-1 Inhibitor / Unkown
HY-181629 ZSTK3744 free base / Unkown
HY-181629A ZSTK3744 / Unkown
HY-RS14546 TIPARP Human Pre-designed siRNA Set A / Unkown
HY-RS14547 Tiparp Mouse Pre-designed siRNA Set A / Unkown
HY-RS14548 Tiparp Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tiparp NCBI NCBI:25976