Hjv - hemojuvelin BMP co-receptor Gene

Also Known as Hfe2; Rgmc

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 310681

Summary

Predicted to enable BMP binding activity; coreceptor activity; and Transferrin Receptor binding activity. Predicted to contribute to BMP Receptor activity. Predicted to be involved in several processes, including cellular iron ion homeostasis; protein autoprocessing; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within iron ion homeostasis; negative regulation of BMP signaling pathway; and positive regulation of transcription by RNA polymerase II. Located in basolateral plasma membrane. Human ortholog(s) of this gene implicated in hemochromatosis and hemochromatosis type 2A. Orthologous to human HJV (hemojuvelin BMP co-receptor). [provided by Alliance of Genome Resources, Apr 2022]

Hjv Products (1)

mRNA Protein Name
NM_001012080.2 NP_001012080.1 hemojuvelin precursor

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence Verweise Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
16932966 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hemojuvelin

  • RGM domain family member C

  • hemochromatosis type 2 (juvenile) (human homolog)

  • hemochromatosis type 2 protein homolog

  • hemojuvelin BMP coreceptor

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-147278A Manusiran sodium Inhibitor / Phase 2
Inhibitory Antibodies (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P991637 Exerenibart Inhibitor 98.00% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-147278 Manusiran Inhibitor / Unkown
HY-RS06191 HJV Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18590 Hjv Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25075 Hjv Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hjv NCBI NCBI:148738