Bmpr1b - bone morphogenetic protein receptor type 1B Gene

Also Known as CFK-43a

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 310914

About Bmpr1b

Primary_assembly 2: 230,541,558-230,871,368 reverse strand.mRatBN7.2:CM026975.1

This gene has 4 transcripts (splice variants), 290 orthologues, 11 paralogues and is associated with 17 phenotypes. Biased expression in Kidney (RPKM 67.5), Brain (RPKM 36.2) and 6 other tissues.

Summary

Predicted to enable several functions, including ATP binding activity; enzyme activator activity; and transmembrane receptor protein serine/threonine kinase activity. Predicted to be involved in several processes, including ovarian cumulus expansion; positive regulation of bone mineralization; and positive regulation of osteoblast differentiation. Predicted to act upstream of or within several processes, including cartilage development; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; and retinal ganglion cell axon guidance. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in brachydactyly type A1D; brachydactyly type A2; and osteochondrodysplasia. Orthologous to human BMPR1B (bone morphogenetic protein receptor type 1B). [provided by Alliance of Genome Resources, Apr 2022]

Bmpr1b Products (1)

mRNA Protein Name
NM_001024259.3 NP_001019430.2 bone morphogenetic protein receptor type-1B

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
21185359 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
21185359 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bmpr1b Protein Structure

Activin_recp

Activin_recp: pfam01064 (29 - 105)

STKc_BMPR1b

STKc_BMPR1b: cd14219 (197 - 501)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 502 a.a.
Protein Preferred Names Protein Names

bone morphogenetic protein receptor type-1B

  • bone morphogenetic protein binding serine/threonine kinase receptor

  • bone morphogenetic protein receptor, type IB

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01549 BMPR1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01550 Bmpr1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01551 Bmpr1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174774 Human BMPR1B mRNA / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991882 Anti-BMPR1B Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bmpr1b NCBI NCBI:658