EIF4E3 - eukaryotic translation initiation factor 4E family member 3 Gene

Also Known as eIF-4E3; eIF4E-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 317649

About EIF4E3

Cytogenetic location: 3p13 Genomic coordinates (GRCh38): 3:71,659,363-71,754,773 (from NCBI)

This gene has 10 transcripts (splice variants), 263 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 11.9), brain (RPKM 7.2) and 25 other tissues.

Summary

EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004 [PubMed 15153109]).[supplied by OMIM, Mar 2008]

EIF4E3 Products (5)

mRNA Protein Name
NM_001134649.3 NP_001128121.1 eukaryotic translation initiation factor 4E type 3 isoform b
NM_001134650.1 NP_001128122.1 eukaryotic translation initiation factor 4E type 3 isoform b
NM_001134651.2 NP_001128123.1 eukaryotic translation initiation factor 4E type 3 isoform a
NM_001282886.2 NP_001269815.1 eukaryotic translation initiation factor 4E type 3 isoform b
NM_173359.5 NP_775495.1 eukaryotic translation initiation factor 4E type 3 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF4E3 Protein Structure

IF4E

IF4E: Eukaryotic initiation factor 4E (48 - 211)

  • 0
  • 100
  • 200
  • 224 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 4E type 3

Related Diseases

Diseases Alias
Thymus Lymphoma

  • Thymic Lymphoma
Eyelid Disease

  • Eyelid Diseases

  • Eyelid Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04276 EIF4E3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris EIF4E3 VGNC VGNC:40285
Rattus norvegicus EIF4E3 RGD RGD:1586185
Felis catus EIF4E3 VGNC VGNC:61792
Mus musculus EIF4E3 MGD MGI:1914142
Bos taurus EIF4E3 VGNC VGNC:28411
Others EIF4E3 NCBI