HOXB3 - homeobox B3 Gene

Also Known as HOX2; HOX2G; Hox-2.7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3213

About HOXB3

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,548,870-48,590,241 (from NCBI)

This gene has 13 transcripts (splice variants), 187 orthologues and 42 paralogues. Broad expression in kidney (RPKM 1.6), fat (RPKM 1.3) and 21 other tissues.

Summary

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML). [provided by RefSeq, Jul 2008]

HOXB3 Products (6)

mRNA Protein Name
NM_001330322.2 NP_001317251.1 homeobox protein Hox-B3 isoform 2
NM_001330323.1 NP_001317252.1 homeobox protein Hox-B3 isoform 3
NM_001384747.1 NP_001371676.1 homeobox protein Hox-B3 isoform 1
NM_001384749.1 NP_001371678.1 homeobox protein Hox-B3 isoform 1
NM_001384750.1 NP_001371679.1 homeobox protein Hox-B3 isoform 2
NM_002146.4 NP_002137.4 homeobox protein Hox-B3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
9556594 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7913891 GOA
Biological Process GO Annotation Evidence References Source
involved in angiogenesis IEP
IEP: Inferred from expression pattern
17972163 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9556594 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXB3 Protein Structure

Homeobox

Homeobox: Homeobox domain (189 - 245)

DUF4074

DUF4074: Domain of unknown function (DUF4074) (364 - 429)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 431 a.a.
Protein Preferred Names Protein Names

homeobox protein Hox-B3

  • homeo box 2G

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06307 HOXB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21597 Hoxb3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28115 Hoxb3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus HOXB3 VGNC VGNC:29919
Felis catus HOXB3 VGNC VGNC:67623
Rattus norvegicus HOXB3 RGD RGD:1310780
Mus musculus HOXB3 MGD MGI:96184
Canis familiaris HOXB3 VGNC VGNC:41751
Others HOXB3 NCBI