2. Gene
  3. HOXB3 - homeobox B3 Gene

HOXB3 - homeobox B3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HOX2; HOX2G; Hox-2.7

Gene ID: 3213 | Gene type: protein coding

About HOXB3

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,548,870-48,590,241 (from NCBI)

This gene has 13 transcripts (splice variants), 187 orthologues and 42 paralogues. Broad expression in kidney (RPKM 1.6), fat (RPKM 1.3) and 21 other tissues.

Summary

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML). [provided by RefSeq, Jul 2008]

HOXB3 Products(6)

mRNA Protein Name
NM_001330322.2 NP_001317251.1 homeobox protein Hox-B3 isoform 2
NM_001330323.1 NP_001317252.1 homeobox protein Hox-B3 isoform 3
NM_001384747.1 NP_001371676.1 homeobox protein Hox-B3 isoform 1
NM_001384749.1 NP_001371678.1 homeobox protein Hox-B3 isoform 1
NM_001384750.1 NP_001371679.1 homeobox protein Hox-B3 isoform 2
NM_002146.4 NP_002137.4 homeobox protein Hox-B3 isoform 1

HOXB3 Protein Structure

Homeobox

Homeobox: Homeobox domain (189 - 245)

DUF4074

DUF4074: Domain of unknown function (DUF4074) (364 - 429)

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  • 400
  • 431 a.a.
Protein Preferred Names Protein Names

homeobox protein Hox-B3

homeo box 2G

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06307 HOXB3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus HOXB3 VGNC VGNC:29919
Felis catus HOXB3 VGNC VGNC:67623
Rattus norvegicus HOXB3 RGD RGD:1310780
Mus musculus HOXB3 MGD MGI:96184
Canis familiaris HOXB3 VGNC VGNC:41751