Il1rapl1 - interleukin 1 receptor accessory protein-like 1 Gene

Also Known as IL1R8; MRX34; OPHN4; IL1RAPL; TIGIRR-2; IL1RAPL-1; C030039N24; 6330532G10Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 331461

Summary

Enables signaling receptor binding activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; nervous system development; and positive regulation of nervous system development. Located in cell surface and dendrite. Is expressed in central nervous system; dorsal root ganglion; eye; lung; and trigeminal nerve. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 21. Orthologous to human IL1RAPL1 (interleukin 1 receptor accessory protein like 1). [provided by Alliance of Genome Resources, Apr 2022]

Il1rapl1 Products (1)

mRNA Protein Name
NM_001160403.2 NP_001153875.1 interleukin-1 receptor accessory protein-like 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21940441 MGI
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
21940441 MGI
Biological Process GO Annotation Evidence References Source
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
IDA: Inferred from direct assay
21940441 MGI
involved in neuron differentiation IDA
IDA: Inferred from direct assay
21940441 MGI
involved in positive regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
21940441 MGI
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
21940441 MGI
involved in positive regulation of synapse assembly IDA
IDA: Inferred from direct assay
25908590 MGI
involved in presynaptic membrane assembly IMP
IMP: Inferred from mutant phenotype
21940441 MGI
involved in synaptic membrane adhesion IDA
IDA: Inferred from direct assay
21940441 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
21940441 MGI
located in dendrite IDA
IDA: Inferred from direct assay
21940441 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-1 receptor accessory protein-like 1

  • X-linked interleukin-1 receptor accessory protein-like 1

Recombinant Il1rapl1 Proteins

Cat. No. Product Name Accession Purity
HY-P76998 IL1RAPL1 Protein, Mouse (HEK293, Fc) P59823 (R25-T357) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06723 IL1RAPL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17932 Il1rapl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24402 Il1rapl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991468 IMM20324 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il1rapl1 NCBI NCBI:11141