HTR4 - 5-hydroxytryptamine receptor 4 Gene

Also Known as 5-HT4; 5-HT4R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3360

About HTR4

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:148,451,032-148,654,527 (from NCBI)

This gene has 13 transcripts (splice variants), 201 orthologues and 25 paralogues. Biased expression in small intestine (RPKM 2.1), duodenum (RPKM 1.1) and 5 other tissues.

Summary

This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010]

HTR4 Products (8)

mRNA Protein Name
NM_000870.7 NP_000861.1 5-hydroxytryptamine receptor 4 isoform b
NM_001040169.2 NP_001035259.1 5-hydroxytryptamine receptor 4 isoform a
NM_001040173.2 NP_001035263.1 5-hydroxytryptamine receptor 4 isoform i
NM_001040174.1
NM_001040172.2 NP_001035262.2 5-hydroxytryptamine receptor 4 isoform d
NR_104445.2
NM_001286410.1 NP_001273339.1 5-hydroxytryptamine receptor 4 isoform c
NM_199453.3 NP_955525.1 5-hydroxytryptamine receptor 4 isoform g

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled serotonin receptor activity IDA
IDA: Inferred from direct assay
9603189 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28298427 GOA
enables serotonin receptor activity IDA
IDA: Inferred from direct assay
33481771 GOA
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
9603189 GOA
involved in adenylate cyclase-activating serotonin receptor signaling pathway IDA
IDA: Inferred from direct assay
35714614 GOA
involved in large intestinal transit IDA
IDA: Inferred from direct assay
33481771 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15925089 GOA
located in membrane IDA
IDA: Inferred from direct assay
16102731 GOA
is active in plasma membrane IDA
IDA: Inferred from direct assay
10821780 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTR4 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (36 - 312)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
Protein Preferred Names Protein Names

5-hydroxytryptamine receptor 4

  • 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled

  • cardiac 5-HT4 receptor

Related Diseases

Diseases Alias
Major Depressive Disorder

  • Seasonal Affective Disorder

  • Unipolar Depression

  • Depression

  • MDD

  • Depressive Disorder

  • Unipolar Depression, Susceptibility To

  • Major Depressive Disorder 1

  • Major Depressive Disorder, Response To Citalopram Therapy In

  • Major Depressive Disorder 2

  • Winter Depression

  • Single Major Depressive Episode

  • Sad

  • Clinical Depression

  • Major Depression

  • Depressive Syndrome

  • Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

  • Seasonal Affective Disorder, Susceptibility To

  • Recurrent Major Depression

  • Affective Disorder, Seasonal

  • Depression In A Seasonal Pattern

  • Depression

  • Seasonal

  • Major Depressive Disorder With A Seasonal Pattern

  • Seasonal Depression

  • Seasonal Mood Disorder

  • Mental Depression

  • Recurrent Major Depressive Episodes
Irritable Bowel Syndrome

  • Irritable Colon

  • Psychogenic Ibs

  • Ibs - [Irritable Bowel Syndrome]

  • Spastic Bowel Syndrome
Headache

  • Headache Disorder
Anxiety

  • Anxiety Disorder

  • Anxiety Disorders

  • Anxiety State

  • Anxieties

  • Anxiety Neurosis
Gastrointestinal System Disease

  • Gastrointestinal Disease

  • Gastrointestinal Diseases

  • Alimentary System Disease

  • Digestive System Disorder

  • Gastroenteropathy

  • Gastrointestinal Disorder

  • Git Disease

  • Digestive System Diseases

  • Gastrointestinal Disorders

  • Digestive System Disease

  • Digestive System Disorders
Colonic Pseudo-Obstruction

  • Primary Chronic Pseudo-Obstruction Of Colon
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Autism Spectrum Disorder

  • Asd

  • Autism Spectrum Disorders

  • Autistic Continuum

  • Pervasive Developmental Disorder

  • Pervasive Development Disorder

  • Autistic Behavior

  • Autistic Disorder

  • Autistic

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Childhood Autism

  • Kanner Syndrome

  • Pervasive Developmental Delay Nos

  • Pervasive Developmental Disorder, Not Otherwise Specified
Functional Gastric Disease
Pylorospasm
Constipation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14153A Tegaserod maleate 99.90% Unkown
HY-14153 Tegaserod 99.71% Unkown

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-14153S Tegaserod-d11 / Unkown
HY-RS06474 HTR4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06475 Htr4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06476 Htr4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HTR4 VGNC VGNC:41831
Bos taurus HTR4 VGNC VGNC:30000
Mus musculus HTR4 MGD MGI:109246
Felis catus HTR4 VGNC VGNC:67675
Macaca mulatta HTR4 VGNC VGNC:73544
Rattus norvegicus HTR4 RGD RGD:2850
Others HTR4 NCBI