Mia2 - MIA SH3 domain ER export factor 2 Gene

Also Known as Mea6; Mgea; Mgea6; Ctage5; D12Bwg0579e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 338320

Summary

This gene encodes a protein that is involved in endoplasmic reticulum-to-Golgi trafficking and regulation of Cholesterol metabolism. Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species. Additionally, alternative splicing in these transcripts results in multiple transcript variants encoding diverse isoforms. A mutation in this gene (couch-potato or cpto) may result in low levels of plasma Cholesterol and triglycerides. [provided by RefSeq, Sep 2016]

Mia2 Products (12)

mRNA Protein Name
NM_001165253.3 NP_001158725.1 melanoma inhibitory activity protein 2 isoform 4
NM_001165254.3 NP_001158726.1 melanoma inhibitory activity protein 2 isoform 5
NM_001329047.2 NP_001315976.1 melanoma inhibitory activity protein 2 isoform 1 precursor
NM_001368839.1 NP_001355768.1 melanoma inhibitory activity protein 2 isoform 6 precursor
NM_001374760.1 NP_001361689.1 melanoma inhibitory activity protein 2 isoform 7
NM_146034.5 NP_666146.3 melanoma inhibitory activity protein 2 isoform 3
NM_001165253.3 NP_001158725.1 melanoma inhibitory activity protein 2 isoform 4
NM_001165254.3 NP_001158726.1 melanoma inhibitory activity protein 2 isoform 5
NM_001329047.2 NP_001315976.1 melanoma inhibitory activity protein 2 isoform 1 precursor
NM_001368839.1 NP_001355768.1 melanoma inhibitory activity protein 2 isoform 6 precursor
NM_001374760.1 NP_001361689.1 melanoma inhibitory activity protein 2 isoform 7
NM_146034.5 NP_666146.3 melanoma inhibitory activity protein 2 isoform 3

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
21807889 MGI
acts upstream of or within triglyceride homeostasis IMP
IMP: Inferred from mutant phenotype
21807889 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

melanoma inhibitory activity protein 2

  • CTAGE family member 5 ER export factor

  • CTAGE family, member 5

  • cutaneous T-cell lymphoma-associated antigen 5 homolog

  • melanoma inhibitory activity 2

  • meningioma expressed antigen 6 (coiled-coil proline-rich)

  • protein cTAGE-5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08420 MIA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21376 Mia2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27895 Mia2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mia2 NCBI NCBI:4253