NLRP14 - NLR family pyrin domain containing 14 Gene

Homo sapiens

Also known as NOD5; PAN8; GC-LRR; NALP14; CLR11.2

Gene ID: 338323 | Gene type: protein coding

About NLRP14

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:7,020,446-7,090,900 (from NCBI)

This gene has 1 transcript (splice variant), 99 orthologues and 20 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, Caspase-1 and caspase-5. [provided by RefSeq, Jul 2008]

NLRP14 Products(1)

mRNA	Protein	Name
NM_176822.4	NP_789792.1	NACHT, LRR and PYD domains-containing protein 14

NLRP14 Protein Structure

PYRIN

NACHT

LRR_6

0
200
400
600
800
1000
1093 a.a.

Protein Preferred Names

Protein Names

NACHT, LRR and PYD domains-containing protein 14

NACHT, LRR and PYD containing protein 14

Related Diseases

Diseases

Alias

Familial Cold Autoinflammatory Syndrome 1

Cold Hypersensitivity	Cold-Induced Autoinflammatory Syndrome, Familial
FCAS1	Fcas
Fcu	Cryopyrin-Associated Periodic Syndrome 1
Caps1	Familial Cold Urticaria
Cold Urticaria, Familial	Familial Cold Inflammatory Syndrome 1
Familial Cold-Induced Autoinflammatory Syndrome	Autoinflammatory Syndrome, Cold, Familial, Type 1

Petrositis

Acute Petrositis	Chronic Petrositis
Inflammation Of Petrous Bone	Osteitis Of Petrous Bone
Osteomyelitis Of Petrous Bone

Steroid-Induced Glaucoma

Corticosteroid-Induced Glaucoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09353	NLRP14 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NLRP14	RGD	RGD:1598218
Felis catus	NLRP14	VGNC	VGNC:63830
Canis familiaris	NLRP14	VGNC	VGNC:43847
Bos taurus	NLRP14	VGNC	VGNC:32116
Mus musculus	NLRP14	MGD	MGI:1924108
Macaca mulatta	NLRP14	VGNC	VGNC:75231

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