NLRP14 - NLR family pyrin domain containing 14 Gene

Also Known as NOD5; PAN8; GC-LRR; NALP14; CLR11.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 338323

About NLRP14

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:7,020,446-7,090,900 (from NCBI)

This gene has 1 transcript (splice variant), 99 orthologues and 20 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, Caspase-1 and caspase-5. [provided by RefSeq, Jul 2008]

NLRP14 Products (1)

mRNA Protein Name
NM_176822.4 NP_789792.1 NACHT, LRR and PYD domains-containing protein 14

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
16931801 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NLRP14 Protein Structure

PYRIN

PYRIN: PAAD/DAPIN/Pyrin domain (12 - 93)

NACHT

NACHT: NACHT domain (178 - 345)

LRR_6

LRR_6: Leucine Rich repeat (728 - 751)

LRR_6

LRR_6: Leucine Rich repeat (786 - 808)

LRR_6

LRR_6: Leucine Rich repeat (842 - 863)

LRR_6

LRR_6: Leucine Rich repeat (899 - 921)

LRR_6

LRR_6: Leucine Rich repeat (956 - 978)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1093 a.a.
Protein Preferred Names Protein Names

NACHT, LRR and PYD domains-containing protein 14

  • NACHT, LRR and PYD containing protein 14

Related Diseases

Diseases Alias
Familial Cold Autoinflammatory Syndrome 1

  • Cold Hypersensitivity

  • Cold-Induced Autoinflammatory Syndrome, Familial

  • FCAS1

  • Fcas

  • Fcu

  • Cryopyrin-Associated Periodic Syndrome 1

  • Caps1

  • Familial Cold Urticaria

  • Cold Urticaria, Familial

  • Familial Cold Inflammatory Syndrome 1

  • Familial Cold-Induced Autoinflammatory Syndrome

  • Autoinflammatory Syndrome, Cold, Familial, Type 1
Petrositis

  • Acute Petrositis

  • Chronic Petrositis

  • Inflammation Of Petrous Bone

  • Osteitis Of Petrous Bone

  • Osteomyelitis Of Petrous Bone
Steroid-Induced Glaucoma

  • Corticosteroid-Induced Glaucoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09353 NLRP14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NLRP14 RGD RGD:1598218
Felis catus NLRP14 VGNC VGNC:63830
Canis familiaris NLRP14 VGNC VGNC:43847
Bos taurus NLRP14 VGNC VGNC:32116
Mus musculus NLRP14 MGD MGI:1924108
Macaca mulatta NLRP14 VGNC VGNC:75231
Others NLRP14 NCBI