QRFP - pyroglutamylated RFamide peptide Gene

Also Known as P518; 26RFa

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 347148

About QRFP

Cytogenetic location: 9q34.12 Genomic coordinates (GRCh38): 9:130,892,707-130,896,812 (from NCBI)

This gene has 2 transcripts (splice variants) and 93 orthologues. Low expression observed in reference dataset.

Summary

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. The encoded products are members of the RFamide family of neuropeptides, characterized by their common protein C-terminus consisting of an arginine (R) and an amidated phenylalanine (F). These products include the neuropeptides 26RFa and the N-terminally extended form, 43RFa. Both of these neuropeptides bind to the pyroglutamylated RFamide peptide receptor (QRFPR) and may regulate blood pressure, reproduction and food intake in rodents. [provided by RefSeq, Jul 2015]

QRFP Products (1)

mRNA Protein Name
NM_198180.3 NP_937823.1 orexigenic neuropeptide QRFP preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables neuropeptide hormone activity IDA
IDA: Inferred from direct assay
14657341 GOA
Biological Process GO Annotation Evidence References Source
involved in neuropeptide signaling pathway IDA
IDA: Inferred from direct assay
14657341 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

QRFP Protein Structure

RFamide_26RFa

RFamide_26RFa: Orexigenic neuropeptide Qrfp/P518 (2 - 135)

  • 0
  • 100
  • 136 a.a.
Protein Preferred Names Protein Names

orexigenic neuropeptide QRFP

  • P518 precursor protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11504 QRFP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus QRFP MGD MGI:3630329
Rattus norvegicus QRFP RGD RGD:735020
Canis familiaris QRFP VGNC VGNC:45235
Felis catus QRFP VGNC VGNC:102972
Bos taurus QRFP VGNC VGNC:33600
Others QRFP NCBI